Sterol carrier protein-2

被引：106

作者：

Seedorf, U ^{[1
]}

Ellinghaus, P ^{[1
]}

Nofer, JR ^{[1
]}

机构：

[1] Univ Munster, Inst Arteriosclerosis Res, Inst Clin Chem & Lab Med, Interdisciplinary Ctr Clin Res, D-48149 Munster, Germany

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS | 2000年 / 1486卷 / 01期

关键词：

sterol carrier protein-2; cholesterol; peroxisome; beta-oxidation; acyl-coenzyme A;

D O I：

10.1016/S1388-1981(00)00047-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The compartmentalization of cholesterol metabolism implies target-specific cholesteroI trafficking between the endoplasmic reticulum, plasma membrane, lysosomes, mitochondria and peroxisomes. One hypothesis has been that sterol carrier protein-2 (SCP2, also known as the non-specific lipid transfer protein) acts in cholesterol transport through the cytoplasm. Recent studies employing gene targeting in mice showed, however, that mice lacking SCP2 and the related putative sterol carrier known as SCPx, develop a defect in peroxisomal P-oxidation. In addition, diminished peroxisomal a-oxidation of phytanic acid (3,7,11,15-tetramethylhexadecanoic acid) in these null mice was attributed to the absence of SCP2 which has a number of properties supporting a function as carrier for fatty acyl-CoAs rather than for sterols. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：45 / 54

页数：10

共 64 条

[11] Hepatocellular and hepatic peroxisomal alterations in mice with a disrupted peroxisomal fatty acyl-coenzyme A oxidase gene [J].