Sterol carrier protein-2

被引：106

作者：

Seedorf, U ^{[1
]}

Ellinghaus, P ^{[1
]}

Nofer, JR ^{[1
]}

机构：

[1] Univ Munster, Inst Arteriosclerosis Res, Inst Clin Chem & Lab Med, Interdisciplinary Ctr Clin Res, D-48149 Munster, Germany

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS | 2000年 / 1486卷 / 01期

关键词：

sterol carrier protein-2; cholesterol; peroxisome; beta-oxidation; acyl-coenzyme A;

D O I：

10.1016/S1388-1981(00)00047-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The compartmentalization of cholesterol metabolism implies target-specific cholesteroI trafficking between the endoplasmic reticulum, plasma membrane, lysosomes, mitochondria and peroxisomes. One hypothesis has been that sterol carrier protein-2 (SCP2, also known as the non-specific lipid transfer protein) acts in cholesterol transport through the cytoplasm. Recent studies employing gene targeting in mice showed, however, that mice lacking SCP2 and the related putative sterol carrier known as SCPx, develop a defect in peroxisomal P-oxidation. In addition, diminished peroxisomal a-oxidation of phytanic acid (3,7,11,15-tetramethylhexadecanoic acid) in these null mice was attributed to the absence of SCP2 which has a number of properties supporting a function as carrier for fatty acyl-CoAs rather than for sterols. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：45 / 54

页数：10

共 64 条

[1] PEROXISOME PROLIFERATING SULFUR-SUBSTITUTED AND OXY-SUBSTITUTED FATTY-ACID ANALOGS ARE ACTIVATED TO ACYL COENZYME-A THIOESTERS [J].

AARSLAND, A ;

BERGE, RK .

BIOCHEMICAL PHARMACOLOGY, 1991, 41 (01) :53-61

[2]

Barnes TM, 1996, J NEUROCHEM, V67, P46

[3] Sterol carrier protein-2 overexpression enhances sterol cycling and inhibits cholesterol ester synthesis and high density lipoprotein cholesterol secretion [J].

Baum, CL ;

Reschly, EJ ;

Gayen, AK ;

Groh, ME ;

Schadick, K .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (10) :6490-6498

[4] CORRELATION BETWEEN THE CELLULAR-LEVEL OF LONG-CHAIN ACYL-COA, PEROXISOMAL BETA-OXIDATION, AND PALMITOYL-COA HYDROLASE ACTIVITY IN RAT-LIVER - ARE THE 2 ENZYME-SYSTEMS REGULATED BY A SUBSTRATE-INDUCED MECHANISM [J].

BERGE, RK ;

AARSLAND, A .

BIOCHIMICA ET BIOPHYSICA ACTA, 1985, 837 (02) :141-151

[5] ASYMMETRY AND TRANSPOSITION RATES OF PHOSPHATIDYLCHOLINE IN RAT ERYTHROCYTE-GHOSTS [J].

BLOJ, B ;

ZILVERSMIT, DB .

BIOCHEMISTRY, 1976, 15 (06) :1277-1283

[6] Complete genome sequence of the methanogenic archaeon, Methanococcus jannaschii [J].

Bult, CJ ;

White, O ;

Olsen, GJ ;

Zhou, LX ;

Fleischmann, RD ;

Sutton, GG ;

Blake, JA ;

FitzGerald, LM ;

Clayton, RA ;

Gocayne, JD ;

Kerlavage, AR ;

Dougherty, BA ;

Tomb, JF ;

Adams, MD ;

Reich, CI ;

Overbeek, R ;

Kirkness, EF ;

Weinstock, KG ;

Merrick, JM ;

Glodek, A ;

Scott, JL ;

Geoghagen, NSM ;

Weidman, JF ;

Fuhrmann, JL ;

Nguyen, D ;

Utterback, TR ;

Kelley, JM ;

Peterson, JD ;

Sadow, PW ;

Hanna, MC ;

Cotton, MD ;

Roberts, KM ;

Hurst, MA ;

Kaine, BP ;

Borodovsky, M ;

Klenk, HP ;

Fraser, CM ;

Smith, HO ;

Woese, CR ;

Venter, JC .

SCIENCE, 1996, 273 (5278) :1058-1073

[7] A second isoform of 3-ketoacyl-CoA thiolase found in Caenorhabditis elegans, which is similar to sterol carrier protein x but lacks the sequence of sterol carrier protein 2 [J].

BunYa, M ;

Maebuchi, M ;

Hashimoto, T ;

Yokota, S ;

Kamiryo, T .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1997, 245 (02) :252-259

[8] Niemann-Pick C1 disease gene: Homology to mediators of cholesterol homeostasis [J].

Carstea, ED ;

Morris, JA ;

Coleman, KG ;

Loftus, SK ;

Zhang, D ;

Cummings, C ;

Gu, J ;

Rosenfeld, MA ;

Pavan, WJ ;

Krizman, DB ;

Nagle, J ;

Polymeropoulos, MH ;

Sturley, SL ;

Ioannou, YA ;

Higgins, ME ;

Comly, M ;

Cooney, A ;

Brown, A ;

Kaneski, CR ;

BlanchetteMackie, EJ ;

Dwyer, NK ;

Neufeld, EB ;

Chang, TY ;

Liscum, L ;

Strauss, JF ;

Ohno, K ;

Zeigler, M ;

Carmi, R ;

Sokol, J ;

Markie, D ;

ONeill, RR ;

vanDiggelen, OP ;

Elleder, M ;

Patterson, MC ;

Brady, RO ;

Vanier, MT ;

Pentchev, PG ;

Tagle, DA .

SCIENCE, 1997, 277 (5323) :228-231

[9] Further characterization of the peroxisomal 3-hydroxyacyl-CoA dehydrogenases from rat liver - Relationship between the different dehydrogenases and evidence that fatty acids and the C-27 bile acids di- and tri-hydroxycoprostanic acids are metabolized by separate multifunctional proteins [J].

DieuaideNoubhani, M ;

Novikov, D ;

Baumgart, E ;

Vanhooren, JCT ;

Fransen, M ;

Goethals, M ;

Vandekerckhove, J ;

VanVeldhoven, PP ;

Mannaerts, GP .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1996, 240 (03) :660-666

[10] Phytanic acid activates the peroxisome proliferator-activated receptor α (PPARα) in sterol carrier protein 2- sterol carrier protein x-deficient mice [J].

Ellinghaus, P ;

Wolfrum, C ;

Assmann, G ;

Spener, F ;

Seedorf, U .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (05) :2766-2772

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