Preparation of nano-chitosan Schiff-base copper complexes and their anticancer activity

被引：53

作者：

Wang, Rong-Min ^{[1
]}

He, Nai-Pu ^{[1
]}

Song, Peng-Fei ^{[1
]}

He, Yu-Feng ^{[1
]}

Ding, Lan ^{[2
]}

Lei, Zi-Qiang ^{[1
]}

机构：

[1] NW Normal Univ, Key Lab Polymer Mat Gansu Prov, Lanzhou 730070, Peoples R China

[2] NW Normal Univ, Dept Biol, Lanzhou 730070, Peoples R China

来源：

POLYMERS FOR ADVANCED TECHNOLOGIES | 2009年 / 20卷 / 12期

基金：

芬兰科学院;

关键词：

chitosan; polysaccharides; nanocomposites; metal-polymer complexes; biological applications of polymers; HEXA-N-ACETYLCHITOHEXAOSE; ANTITUMOR-ACTIVITY; DELIVERY-SYSTEM; DNA; PLATINUM; CHEMISTRY; LIGANDS; PERSPECTIVES; CHITOHEXAOSE; PALLADIUM;

D O I：

10.1002/pat.1348

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

A new kind of nano-chitosan Schiff-base Cu complexes with particle sizes of 350 nm were prepared by combination of nano-chitosan, Cu and Schiff-base, and characterized by FT-IR spectra, TEM, DLS and elemental analysis. The modes and mechanism of interaction of the copper complexes with DNA were studied by the fluorescent probe method and electrophoresis analysis. The results suggest that the Cu complexes bound to DNA by electrostatic and intercalation modes. The anticancer activity of the Cu complexes was evaluated by Sulforhodamine B (SRB) assay in vitro. Nano-chitosan and their Schiff-base Cu complexes inhibited the growth of the liver cancer cell lines SMMC-7721 in vitro. The inhibition rate of Schiff-base Cu complexes was higher than that of nano-chitosan. Nano-chitosan combining with Schiff-base and Cu improved their anticancer activity, which ascribed to the synergistic effect between the chitosan matrix and the planar construction of the Cu complexes. Copyright (C) 2008 John Wiley & Sons, Ltd.

引用

页码：959 / 964

页数：6

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