Body mass index and colorectal cancer risk: A Mendelian randomization study

被引：38

作者：

Suzuki, Shiori ^{[1
,2
]}

Goto, Atsushi ^{[1
,3
]}

Nakatochi, Masahiro ^{[4
]}

Narita, Akira ^{[5
]}

Yamaji, Taiki ^{[1
]}

Sawada, Norie ^{[1
]}

Katagiri, Ryoko ^{[1
]}

Iwagami, Masao ^{[6
]}

Hanyuda, Akiko ^{[1
]}

Hachiya, Tsuyoshi ^{[7
]}

Sutoh, Yoichi ^{[7
]}

Oze, Isao ^{[8
]}

Koyanagi, Yuriko N. ^{[9
]}

Kasugai, Yumiko ^{[8
,10
]}

Taniyama, Yukari ^{[9
]}

Ito, Hidemi ^{[9
,11
]}

Ikezaki, Hiroaki ^{[12
]}

Nishida, Yuichiro ^{[13
]}

Tamura, Takashi ^{[14
]}

Mikami, Haruo ^{[15
]}

Takezaki, Toshiro ^{[16
]}

Suzuki, Sadao ^{[17
]}

Ozaki, Etsuko ^{[18
]}

Kuriki, Kiyonori ^{[19
]}

Takashima, Naoyuki ^{[20
,21
]}

Arisawa, Kokichi ^{[22
]}

Takeuchi, Kenji ^{[14
]}

Tanno, Kozo ^{[23
]}

Shimizu, Atsushi ^{[7
]}

Tamiya, Gen ^{[24
]}

Hozawa, Atsushi ^{[25
]}

Kinoshita, Kengo ^{[24
]}

Wakai, Kenji ^{[14
]}

Sasaki, Makoto ^{[26
]}

Yamamoto, Masayuki ^{[27
]}

Matsuo, Keitaro ^{[8
,10
]}

Tsugane, Shoichiro ^{[28
]}

Iwasaki, Motoki ^{[1
,2
]}

机构：

[1] Natl Canc Ctr, Div Epidemiol, Ctr Publ Hlth Sci, Tokyo, Japan

[2] Jikei Univ, Sch Med, Div Canc Med, Tokyo, Japan

[3] Yokohama City Univ, Grad Sch Data Sci, Dept Hlth Data Sci, Yokohama, Kanagawa, Japan

[4] Nagoya Univ, Grad Sch Med, Dept Integrated Hlth Sci, Publ Hlth Informat Unit, Nagoya, Aichi, Japan

[5] Tohoku Univ, Tohoku Med Megabank Org, Dept Hlth Record Informat, Sendai, Miyagi, Japan

[6] Univ Tsukuba, Dept Hlth Serv Res, Fac Med, Tsukuba, Ibaraki, Japan

[7] Iwate Med Univ, Iwate Tohoku Med Megabank Org, Div Biomed Informat Anal, Yahaba, Iwate, Japan

[8] Aichi Canc Ctr, Res Inst, Div Canc Epidemiol & Prevent, Nagoya, Aichi, Japan

[9] Aichi Canc Ctr, Res Inst, Div Canc Informat & Control, Nagoya, Aichi, Japan

[10] Nagoya Univ, Grad Sch Med, Div Canc Epidemiol, Nagoya, Aichi, Japan

[11] Nagoya Univ, Grad Sch Med, Div Descript Canc Epidemiol, Nagoya, Aichi, Japan

[12] Kyushu Univ, Fac Med Sci, Dept Comprehens Gen Internal Med, Fukuoka, Japan

[13] Saga Univ, Dept Prevent Med, Fac Med, Saga, Japan

[14] Nagoya Univ, Grad Sch Med, Dept Prevent Med, Nagoya, Aichi, Japan

[15] Chiba Canc Ctr, Res Inst, Canc Prevent Ctr, Chiba, Japan

[16] Kagoshima Univ, Grad Sch Med & Dent Sci, Dept Int Isl & Community Med, Kagoshima, Japan

[17] Nagoya City Univ, Grad Sch Med Sci, Dept Publ Hlth, Nagoya, Aichi, Japan

[18] Kyoto Prefectural Univ Med, Grad Sch Med Sci, Dept Epidemiol Community Hlth & Med, Kyoto, Japan

[19] Univ Shizuoka, Sch Food & Nutrit Sci, Lab Publ Hlth, Shizuoka, Japan

[20] Kindai Univ, Fac Med, Dept Publ Hlth, Osaka, Japan

[21] Shiga Univ Med Sci, Dept Publ Hlth, Shiga, Japan

[22] Univ Tokushima, Grad Sch Biomed Sci, Dept Prevent Med, Tokushima, Japan

[23] Iwate Med Univ, Iwate Tohoku Med Megabank Org, Div Clin Res & Epidemiol, Yahaba, Iwate, Japan

[24] Tohoku Univ, Tohoku Med Megabank Org, Dept Integrat Genom, Sendai, Miyagi, Japan

[25] Tohoku Univ, Tohoku Med Megabank Org, Dept Prevent Med & Epidemiol, Sendai, Miyagi, Japan

[26] Iwate Med Univ, Iwate Tohoku Med Megabank Org, Yahaba, Iwate, Japan

[27] Tohoku Univ, Tohoku Med Megabank Org, Sendai, Miyagi, Japan

[28] Natl Canc Ctr, Ctr Publ Hlth Sci, Tokyo, Japan

来源：

CANCER SCIENCE | 2021年 / 112卷 / 04期

关键词：

Asia; body mass index; colorectal cancer; epidemiology; Mendelian randomization; GENETIC-VARIANTS; ASSOCIATION; INSTRUMENTS; OBESITY; BIAS; ADIPOSITY; INSIGHTS; DISEASE; COHORT; JAPAN;

D O I：

10.1111/cas.14824

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Traditional observational studies have reported a positive association between higher body mass index (BMI) and the risk of colorectal cancer (CRC). However, evidence from other approaches to pursue the causal relationship between BMI and CRC is sparse. A two-sample Mendelian randomization (MR) study was undertaken using 68 single nucleotide polymorphisms (SNPs) from the Japanese genome-wide association study (GWAS) and 654 SNPs from the GWAS catalogue for BMI as sets of instrumental variables. For the analysis of SNP-BMI associations, we undertook a meta-analysis with 36 303 participants in the Japanese Consortium of Genetic Epidemiology studies (J-CGE), comprising normal populations. For the analysis of SNP-CRC associations, we utilized 7636 CRC cases and 37 141 controls from five studies in Japan, and undertook a meta-analysis. Mendelian randomization analysis of inverse-variance weighted method indicated that a one-unit (kg/m(2)) increase in genetically predicted BMI was associated with an odds ratio of 1.13 (95% confidence interval, 1.06-1.20; P value <.001) for CRC using the set of 68 SNPs, and an odds ratio of 1.07 (1.03-1.11, 0.001) for CRC using the set of 654 SNPs. Sensitivity analyses robustly showed increased odds ratios for CRC for every one-unit increase in genetically predicted BMI. Our MR analyses strongly support the evidence that higher BMI influences the risk of CRC. Although Asians are generally leaner than Europeans and North Americans, avoiding higher BMI seems to be important for the prevention of CRC in Asian populations.

引用

页码：1579 / 1588

页数：10

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