Inflammation in Benign Prostatic Hyperplasia: A 282 Patients' Immunohistochemical Analysis

被引：240
作者：
Robert, Gregoire [2 ,3 ]
Descazeaud, Aurelien [2 ,4 ]
Nicolaiew, Nathalie [2 ]
Terry, Stephane [2 ]
Sirab, Nanor [2 ]
Vacherot, Francis [2 ]
Maille, Pascale [5 ]
Allory, Yves [2 ,5 ]
de la Taille, Alexandre [1 ,2 ,6 ]
机构：
[1] CHU Henri Mondor, INSERM, Dept Urol, U955 Eq07, F-94000 Creteil, France
[2] Univ Paris 12, Fac Med, Creteil, France
[3] Univ Bordeaux 2, Pellegrin Univ Hosp, Dept Urol, F-33076 Bordeaux, France
[4] CHU Limoges, Dupuytren Hosp, Dept Urol, Limoges, France
[5] Hop Henri Mondor, AP HP, Dept Pathol, F-94010 Creteil, France
[6] Hop Henri Mondor, AP HP, Dept Urol, F-94010 Creteil, France
来源：
PROSTATE | 2009年 / 69卷 / 16期
关键词：
benign prostatic hyperplasia; BPH; inflammation; CD3; CD4; CD8; CD20; CD163; lymphocyte; EXPRESSION; TISSUE; BPH;
D O I：
10.1002/pros.21027
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
INTRODUCTION AND OBJECTIVES. Prostatic inflammation could be a key component in prostate enlargement and benign prostatic hyperplasia (BPH) progression. Our aim was to characterize inflammatory cells infiltrate within BPH tissue and to correlate inflammation and clinical data. MATERIAL AND METHODS. Inflammation was profiled on three clinical outcome tissue microarrays (TMAs), including 282 patients treated by surgery for a complicated and/or symptomatic BPH. Inflammation score was defined by combining six cytological parameters and five markers on immunohistochemistry (IHC). Cytological parameters were lymphocytes, macrophages, and polynuclears leukocytes infiltrates, and three glandular aspect modifications: glandular atrophy, glandular destruction, and tissue fibrosis. IHC markers were CD3, CD4, and CD8 decorating T-lymphocytes, CD20 decorating B-lymphocytes, and CD163 decorating macrophages. RESULTS. The majority of patients had inflammatory cells infiltrating BPH tissues: 81% had T-lymphocytes markers (CD3), 52% had B-lymphocytes markers (CD20), and 82% had macrophages markers (CD163). IPSS score (21 vs. 12; P = 0.02) and prostate volume (77 cm 3 vs. 62 cm 3; P = 0.002) were significantly higher in patients with high-grade prostatic inflammation. CONCLUSION. We characterized inflammatory cells infiltrate in a large cohort of surgically treated BPH specimens. The role of inflammation in BPH development was highlighted by the strong correlation between histological inflammation, IPSS, and prostate volume. Prostate enlargement due to chronic inflammatory process may progressively conduce to BPH progression. Therefore, inflammation is a therapeutic target for BPH. Prostate 69: 1774-1780, 2009. (C) 2009 Wiley-Liss, Inc.
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页码：1774 / 1780
页数：7
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