Modular Segregation of Structural Brain Networks Supports the Development of Executive Function in Youth

被引：275

作者：

Baum, Graham L. ^{[1
]}

Ciric, Rastko ^{[1
]}

Roalf, David R. ^{[1
]}

Betzel, Richard F. ^{[2
]}

Moore, Tyler M. ^{[1
]}

Shinohara, Russell T. ^{[3
]}

Kahn, Ari E. ^{[2
]}

Vandekar, Simon N. ^{[3
]}

Rupert, Petra E. ^{[1
]}

Quarmley, Megan ^{[1
]}

Cook, Philip A. ^{[4
]}

Elliott, Mark A. ^{[4
]}

Ruparel, Kosha ^{[1
]}

Gur, Raquel E. ^{[1
]}

Gur, Ruben C. ^{[1
]}

Bassett, Danielle S. ^{[2
,5
]}

Satterthwaite, Theodore D. ^{[1
]}

机构：

[1] Univ Penn, Dept Psychiat, Philadelphia, PA 19104 USA

[2] Univ Penn, Dept Bioengn, Philadelphia, PA 19104 USA

[3] Univ Penn, Dept Biostat & Epidemiol, Philadelphia, PA 19104 USA

[4] Univ Penn, Dept Radiol, Philadelphia, PA 19104 USA

[5] Univ Penn, Dept Elect & Syst Engn, Philadelphia, PA 19104 USA

来源：

CURRENT BIOLOGY | 2017年 / 27卷 / 11期

基金：

美国国家科学基金会;

关键词：

PROBABILISTIC DIFFUSION TRACTOGRAPHY; RESTING-STATE NETWORKS; HUMAN CEREBRAL-CORTEX; COMMUNITY STRUCTURE; CORTICAL DEVELOPMENT; CONNECTIVITY; CONNECTOME; SYSTEM; ORGANIZATION; MOTION;

D O I：

10.1016/j.cub.2017.04.051

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The human brain is organized into large-scale functional modules that have been shown to evolve in childhood and adolescence. However, it remains unknown whether the underlying white matter architecture is similarly refined during development, potentially allowing for improvements in executive function. In a sample of 882 participants (ages 8-22) who underwent diffusion imaging as part of the Philadelphia Neurodevelopmental Cohort, we demonstrate that structural network modules become more segregated with age, with weaker connections between modules and stronger connections within modules. Evolving modular topology facilitates global network efficiency and is driven by age-related strengthening of hub edges present both within and between modules. Critically, both modular segregation and network efficiency are associated with enhanced executive performance and mediate the improvement of executive functioning with age. Together, results delineate a process of structural network maturation that supports executive function in youth.

引用

页码：1561 / +

页数：20

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