Prostate-Specific Membrane Antigen (PSMA)-Targeted Radionuclide Probes for Imaging and Therapy of Prostate Cancer

被引：8

作者：

Kwon, Hongmok ^{[1
]}

Son, Sang-Hyun ^{[1
]}

Byun, Youngjoo ^{[1
]}

机构：

[1] Korea Univ, Coll Pharm, 2511 Sejong Ro, Sejong 30019, South Korea

来源：

ASIAN JOURNAL OF ORGANIC CHEMISTRY | 2019年 / 8卷 / 09期

基金：

新加坡国家研究基金会;

关键词：

Prostate cancer; PSMA; imaging agents; radionuclide; radiotherapy; GLUTAMATE-CARBOXYPEPTIDASE-II; MOLECULE DRUG CONJUGATE; UREA-BASED INHIBITORS; PRECLINICAL EVALUATION; N-SUCCINIMIDYL; CLICK CHEMISTRY; PSMA INHIBITOR; BIOLOGICAL EVALUATION; CURRENT STATE; HBED-CC;

D O I：

10.1002/ajoc.201900329

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Prostate cancer (PCa) is one of the common cancers among men. Despite the prevalence of PCa, there are still unmet medical needs in the diagnosis and treatment of metastatic prostate cancer. Prostate-specific membrane antigen (PSMA) is a type II zinc-dependent metalloprotease which is highly overexpressed in metastatic PCa. In the last several years, PCa imaging probes targeting PSMA have been developed in academia as well as in industry. Among them, low molecular weight PSMA-targeted ligands based on the Glu-urea-Lys scaffold have been evaluated in preclinical and clinical studies. This review provides an overview of the recent development in PSMA-targeted imaging or therapeutic probes for metastatic PCa.

引用

页码：1588 / 1600

页数：13

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