Genetic predisposition to human disease: allele-specific expression and low-penetrance regulatory loci

被引：35
|
作者：
de la Chapelle, A. [1 ]
机构：
[1] Ohio State Univ, Ctr Comprehens Canc, Human Canc Genet Program, Columbus, OH 43210 USA
来源：
ONCOGENE | 2009年 / 28卷 / 38期
关键词：
allele-specific expression; TGFBR1; APC; DAPK1; TGFBR1;
D O I：
10.1038/onc.2009.194
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The two alleles of a gene can be expressed at different levels, the extreme example being imprinting, a condition in which one allele is totally suppressed. Recently, subtle differences in the expression of the two alleles have been detected in numerous human genes and in a few cases, have been associated with a genetic predisposition to disease. The underlying mechanisms are largely unexplored. Oncogene (2009) 28, 3345-3348; doi: 10.1038/onc.2009.194; published online 13 July 2009
引用
收藏
页码：3345 / 3348
页数：4
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