Genetic predisposition to human disease: allele-specific expression and low-penetrance regulatory loci

被引：35

作者：

de la Chapelle, A. ^{[1
]}

机构：

[1] Ohio State Univ, Ctr Comprehens Canc, Human Canc Genet Program, Columbus, OH 43210 USA

来源：

ONCOGENE | 2009年 / 28卷 / 38期

关键词：

allele-specific expression; TGFBR1; APC; DAPK1; TGFBR1;

D O I：

10.1038/onc.2009.194

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The two alleles of a gene can be expressed at different levels, the extreme example being imprinting, a condition in which one allele is totally suppressed. Recently, subtle differences in the expression of the two alleles have been detected in numerous human genes and in a few cases, have been associated with a genetic predisposition to disease. The underlying mechanisms are largely unexplored. Oncogene (2009) 28, 3345-3348; doi: 10.1038/onc.2009.194; published online 13 July 2009

引用

页码：3345 / 3348

页数：4

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