Curcumin: A potentially powerful tool to reverse cisplatin-induced toxicity

被引：162
作者：
Rezaee, Ramin [1 ]
Momtazi, Amir Abbas [2 ]
Monemi, Alireza [3 ]
Sahebkar, Amirhossein [4 ,5 ]
机构：
[1] North Khorasan Univ Med Sci, Sch Med, Dept Physiol & Pharmacol, Bojnurd, Iran
[2] Mashhad Univ Med Sci, Nanotechnol Res Ctr, Sch Med, Dept Med Biotechnol, Mashhad, Iran
[3] North Khorasan Univ Med Sci, Sch Med, Student Res Comm, Bojnurd, Iran
[4] Mashhad Univ Med Sci, Biotechnol Res Ctr, Mashhad 9177948564, Iran
[5] Univ Western Australia, Royal Perth Hosp, Metab Res Ctr, Sch Med & Pharmacol, Perth, WA, Australia
来源：
PHARMACOLOGICAL RESEARCH | 2017年 / 117卷
关键词：
Curcumin; Cisplatin; Chemotherapy; Resistance; Toxicity; CHRONIC PULMONARY COMPLICATIONS; CANCER CHEMOPREVENTIVE ACTIVITY; RANDOMIZED CONTROLLED-TRIAL; SYSTEMIC OXIDATIVE STRESS; NECROSIS-FACTOR-ALPHA; FATTY LIVER-DISEASE; KAPPA-B ACTIVATION; QUALITY-OF-LIFE; MOLECULAR-MECHANISMS; SULFUR MUSTARD;
D O I：
10.1016/j.phrs.2016.12.037
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Curcumin is a naturally occurring polyphenol isolated from Curcuma longa that has gained considerable interest over the last decades due to its beneficial effects for human health. Moreover, the usage of cisplatin, a platinum -based chemotherapeutic, is associated with several adverse effects affecting the quality of life of the patients. Also, cisplatin therapy is jeopardized by a great challenge of resistance which reduces the efficacy of this drug. In order to conquer these dark sides of cisplatin therapy, curcumin has been widely used to fight against cisplatin-resistant cancer cells and decrease its unwanted side effects (e.g. ototoxicity, nephrotoxicity and neurotoxicity). In this review, we provide a summary of the studies done to show the protective effects of curcumin against cisplatin failure and toxicity. (c) 2016 Elsevier Ltd. All rights reserved.
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收藏
页码：218 / 227
页数：10
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