Curcumin: A potentially powerful tool to reverse cisplatin-induced toxicity

被引：162

作者：

Rezaee, Ramin ^{[1
]}

Momtazi, Amir Abbas ^{[2
]}

Monemi, Alireza ^{[3
]}

Sahebkar, Amirhossein ^{[4
,5
]}

机构：

[1] North Khorasan Univ Med Sci, Sch Med, Dept Physiol & Pharmacol, Bojnurd, Iran

[2] Mashhad Univ Med Sci, Nanotechnol Res Ctr, Sch Med, Dept Med Biotechnol, Mashhad, Iran

[3] North Khorasan Univ Med Sci, Sch Med, Student Res Comm, Bojnurd, Iran

[4] Mashhad Univ Med Sci, Biotechnol Res Ctr, Mashhad 9177948564, Iran

[5] Univ Western Australia, Royal Perth Hosp, Metab Res Ctr, Sch Med & Pharmacol, Perth, WA, Australia

来源：

PHARMACOLOGICAL RESEARCH | 2017年 / 117卷

关键词：

Curcumin; Cisplatin; Chemotherapy; Resistance; Toxicity; CHRONIC PULMONARY COMPLICATIONS; CANCER CHEMOPREVENTIVE ACTIVITY; RANDOMIZED CONTROLLED-TRIAL; SYSTEMIC OXIDATIVE STRESS; NECROSIS-FACTOR-ALPHA; FATTY LIVER-DISEASE; KAPPA-B ACTIVATION; QUALITY-OF-LIFE; MOLECULAR-MECHANISMS; SULFUR MUSTARD;

D O I：

10.1016/j.phrs.2016.12.037

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Curcumin is a naturally occurring polyphenol isolated from Curcuma longa that has gained considerable interest over the last decades due to its beneficial effects for human health. Moreover, the usage of cisplatin, a platinum -based chemotherapeutic, is associated with several adverse effects affecting the quality of life of the patients. Also, cisplatin therapy is jeopardized by a great challenge of resistance which reduces the efficacy of this drug. In order to conquer these dark sides of cisplatin therapy, curcumin has been widely used to fight against cisplatin-resistant cancer cells and decrease its unwanted side effects (e.g. ototoxicity, nephrotoxicity and neurotoxicity). In this review, we provide a summary of the studies done to show the protective effects of curcumin against cisplatin failure and toxicity. (c) 2016 Elsevier Ltd. All rights reserved.

引用

页码：218 / 227

页数：10

共 154 条

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