Somatotopic Arrangement of the Human Primary Somatosensory Cortex Derived From Functional Magnetic Resonance Imaging

被引:21
作者
Willoughby, W. R. [1 ]
Thoenes, Kristina [2 ]
Bolding, Mark [1 ]
机构
[1] Univ Alabama Birmingham, Dept Radiol, Birmingham, AL 35294 USA
[2] Univ Alabama Birmingham, Dept Neurobiol, Birmingham, AL USA
基金
美国国家卫生研究院;
关键词
homunculus; fMRI; somatosensory; topographic maps; MR safe; CEREBRAL-CORTEX; 7; T; REPRESENTATION; FMRI; AREAS; ARCHITECTURE; STIMULATION; MOTOR; FACE;
D O I
10.3389/fnins.2020.598482
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Functional magnetic resonance imaging (fMRI) was used to estimate neuronal activity in the primary somatosensory cortex of six participants undergoing cutaneous tactile stimulation on skin areas spread across the entire body. Differences between the accepted somatotopic maps derived from Penfield's work and those generated by this fMRI study were sought, including representational transpositions or replications across the cortex. MR-safe pneumatic devices mimicking the action of a Wartenberg wheel supplied touch stimuli in eight areas. Seven were on the left side of the body: foot, lower, and upper leg, trunk beneath ribcage, anterior forearm, middle fingertip, and neck above the collarbone. The eighth area was the glabella. Activation magnitude was estimated as the maximum cross-correlation coefficient at a certain phase shift between ideal time series and measured blood oxygen level dependent (BOLD) time courses on the cortical surface. Maximally correlated clusters associated with each cutaneous area were calculated, and cortical magnification factors were estimated. Activity correlated to lower limb stimulation was observed in the paracentral lobule and superomedial postcentral region. Correlations to upper extremity stimulation were observed in the postcentral area adjacent to the motor hand knob. Activity correlated to trunk, face and neck stimulation was localized in the superomedial one-third of the postcentral region, which differed from Penfield's cortical homunculus.
引用
收藏
页数:10
相关论文
共 48 条
[1]   Anatomical and functional properties of the foot and leg representation in areas 3b, 1 and 2 of primary somatosensory cortex in humans: A 7T fMRI study [J].
Akselrod, Michel ;
Martuzzi, Roberto ;
Serino, Andrea ;
van der Zwaag, Wietske ;
Gassert, Roger ;
Blanke, Olaf .
NEUROIMAGE, 2017, 159 :473-487
[2]   Male Urogenital System Mapped Onto the Sensory Cortex: Functional Magnetic Resonance Imaging Evidence [J].
Allen, Kachina ;
Wise, Nan ;
Frangos, Eleni ;
Komisaruk, Barry .
JOURNAL OF SEXUAL MEDICINE, 2020, 17 (04) :603-613
[3]   Somatosensory cortical activation identified by functional MRI in preterm and term infants [J].
Arichi, T. ;
Moraux, A. ;
Melendez, A. ;
Doria, V. ;
Groppo, M. ;
Merchant, N. ;
Combs, S. ;
Burdet, E. ;
Larkman, D. J. ;
Counsell, S. J. ;
Beckmann, C. F. ;
Edwards, A. D. .
NEUROIMAGE, 2010, 49 (03) :2063-2071
[4]   Somatosensory cortex responses to median nerve stimulation: fMRI effects of current amplitude and selective attention [J].
Backes, WH ;
Mess, WH ;
van Kranen-Mastenbroek, V ;
Reulen, JPH .
CLINICAL NEUROPHYSIOLOGY, 2000, 111 (10) :1738-1744
[5]  
BAUMGARTNER C, 1991, EXP BRAIN RES, V87, P641
[6]  
Beck PD, 1996, J COMP NEUROL, V366, P109
[7]   Single-subject fMRI mapping at 7 T of the representation of fingertips in S1: a comparison of event-related and phase-encoding designs [J].
Besle, Julien ;
Sanchez-Panchuelo, Rosa-Maria ;
Bowtell, Richard ;
Francis, Susan ;
Schluppeck, Denis .
JOURNAL OF NEUROPHYSIOLOGY, 2013, 109 (09) :2293-2305
[8]  
Brown-Sequard M., 1968, Archives of Neurology, V19, P347, DOI [10.1001/archneur.1968.00480030125016, DOI 10.1001/ARCHNEUR.1968.00480030125016]
[9]   AFNI: Software for analysis and visualization of functional magnetic resonance neuroimages [J].
Cox, RW .
COMPUTERS AND BIOMEDICAL RESEARCH, 1996, 29 (03) :162-173
[10]   A Data-Driven Multi-scale Technique for fMRI Mapping of the Human Somatosensory Cortex [J].
Da Rocha Amaral, Selene ;
Sanchez Panchuelo, Rosa Maria ;
Francis, Susan .
BRAIN TOPOGRAPHY, 2020, 33 (01) :22-36