Investigation of Potential Inhibitors of Brown Adipose Tissue Induced Thermogenesis

被引：0

作者：

Chen, Changshen ^{[1
]}

机构：

[1] Shanghai World Foreign Language Acad, Shanghai, Peoples R China

来源：

PROCEEDINGS OF 2021 11TH INTERNATIONAL CONFERENCE ON BIOSCIENCE, BIOCHEMISTRY AND BIOINFORMATICS, ICBBB 2021 | 2021年

关键词：

Thermogenesis; Brown adipose tissue; Obesity; UCPI; OBESITY;

D O I：

10.1145/3448340.3448349

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Obesity is a worldwide problem that causes damage to quality of life and the national health care system. There is no effective treatment for obesity, and the development of novel treatment is necessary. Thermogenesis is a process that happens in thermogenic adipose tissue by transferring energy storage into heat and is a potential target for obesity treatment. In this paper, I screened for potential thermogenic inhibitors by cross comparing human and mouse unbiased proteomic profiling to get 3 out of 7 potential inhibitors. By designing genetic engineering approaches, I acquired gain-of-function and loss-of-function tools for further molecular biology regulation studies of my candidates

引用

页码：52 / 60

页数：9

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