Cloning of two novel human importin-alpha subunits and analysis of the expression pattern of the importin-alpha protein family

被引：205
作者：
Kohler, M
Ansieau, S
Prehn, S
Leutz, A
Haller, H
Hartmann, E
机构：
[1] MAX DELBRUCK CTR MOL MED, D-13125 BERLIN, GERMANY
[2] HUMBOLDT UNIV BERLIN, FRANZ VOLHARD CLIN, BERLIN, GERMANY
[3] HUMBOLDT UNIV BERLIN, DEPT BIOCHEM CHARITE, BERLIN, GERMANY
来源：
FEBS LETTERS | 1997年 / 417卷 / 01期
关键词：
nuclear transport; importin-alpha; protein expression; nuclear signaling;
D O I：
10.1016/S0014-5793(97)01265-9
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The import of many proteins into the nucleus is mediated by the importin-alpha/beta heterodimer. While only one importin-beta gene has been found, several forms of importin-alpha have been described. In addition to the three human importin-alpha s already identified, we report here the primary structure of two new human importin-alpha proteins. The five known human importin-alpha subunits can be classified into three subfamilies that appear conserved in higher eukaryotic organisms. We show by immunoblotting that the different importin-alpha subfamilies are expressed in a variety of human tissues and mammalian cell lines. (C) 1997 Federation of European Biochemical Societies.
引用
收藏
页码：104 / 108
页数：5
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