Facile synthesis of amino bicyclo[2.2.1]heptyl alcohol and its application for enantioselective additions of diethylzinc to aldehydes

被引：41
作者：
Hanyu, N
Mino, T
Sakamoto, M
Fujita, T
机构：
[1] Chiba Univ, Fac Engn, Dept Mat Technol, Inage Ku, Chiba 2638522, Japan
[2] Chiba Univ, Grad Sch Sci & Technol, Inage Ku, Chiba 2638522, Japan
来源：
TETRAHEDRON LETTERS | 2000年 / 41卷 / 23期
关键词：
D O I：
10.1016/S0040-4039(00)00637-7
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Enantioselective additions of diethylzinc to aldehydes were demonstrated, and good to moderate enantioselectivities (54 to 95% enantiomeric excess) were obtained. The ligand 4 was prepared from camphor and acetic acid in a facile process of four steps, and the chiral source was only inexpensive (+)-camphor. (C) 2000 Elsevier Science Ltd. All rights reserved.
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页码：4587 / 4590
页数：4
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