Electrochemical behaviors of nicotine and its interaction with DNA

被引：26
|
作者：
Wang, Lu
Xiong, Huayu
Zhang, Xiuhua
Wang, Shengfu [1 ]
机构：
[1] Hubei Univ, Minist Educ, Key Lab Synth & Applicat Organ Funct Mol, Wuhan 430062, Peoples R China
来源：
ELECTROCHEMISTRY COMMUNICATIONS | 2009年 / 11卷 / 11期
关键词：
DNA; Nicotine; Interaction; Electrostatic mode; DPV; GLASSY-CARBON; RUTIN;
D O I：
10.1016/j.elecom.2009.09.012
中图分类号：
O646 [电化学、电解、磁化学];
学科分类号：
081704 ;
摘要：
The studies of the interaction between nicotine and DNA on the solid electrode were proposed for the first time. The electrochemical behaviors of nicotine and its interaction with DNA were explored by differential pulse voltammetry (DPV) at the DNA modified glassy carbon electrode (DNA/GCE). In 0.05 M Na2C2O4 (pH 4.24), nicotine at DNA/GCE showed an irreversible reductive behavior in the range of -1.6 to -1.1 V. The presence of DNA led to the decrease in the peak current of nicotine and the negative shift in the potential, indicating that nicotine could interact with DNA by electrostatic mode. The binding ratio between nicotine and DNA was calculated to be 2:1 and the binding constant was 8.31(+/- 0.36) x 10(2). The interaction between nicotine and DNA could be further verified by UV-vis spectroscopy. (C) 2009 Elsevier B.V. All rights reserved.
引用
收藏
页码：2129 / 2132
页数：4
相关论文
共 50 条
  • [21] Electrochemical studies of pirarubicin and its interaction with DNA at a Co/GC ion implantation modified electrode
    Ma, XM
    Hu, JB
    Li, QL
    CHEMICAL RESEARCH IN CHINESE UNIVERSITIES, 2004, 20 (06) : 751 - 756
  • [22] Electrochemical Studies of Pirarubicin and Its Interaction with DNA at a Co/GC Ion Implantation Modified Electrode
    MA Xiao-mei
    Chemical Research in Chinese Universities, 2004, (06) : 751 - 756
  • [23] Electrochemical behavior of gallic acid interaction with DNA and detection of damage to DNA
    Yang, Zhousheng
    Zhang, Dapeng
    Long, Haiyan
    Liu, Yunchun
    JOURNAL OF ELECTROANALYTICAL CHEMISTRY, 2008, 624 (1-2) : 91 - 96
  • [24] An electrochemical study of 9-chloroacridine redox behavior and its interaction with double-stranded DNA
    Rupar, Jelena
    Aleksic, Mara M.
    Dobricic, Vladimir
    Brboric, Jasmina
    Cudina, Olivera
    BIOELECTROCHEMISTRY, 2020, 135
  • [25] Electrochemical Studies of Cu(phen)edda Interaction with DNA
    Yaw, C. W.
    Tan, W. T.
    Tan, W. S.
    Ng, C. H.
    Yap, W. B.
    Rahman, N. H.
    Zidan, Mohamed
    INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE, 2012, 7 (05): : 4692 - 4701
  • [26] Studies on the interaction between rutin and DNA in the absence and presence of β-cyclodextrin by electrochemical and spectroscopic methods
    Yang, GJ
    Xu, JJ
    Chen, HY
    Leng, ZZ
    CHINESE JOURNAL OF CHEMISTRY, 2004, 22 (11) : 1325 - 1329
  • [27] Electrochemical oxidation of the antitumor antibiotic mitomycin C and in situ evaluation of its interaction with DNA using a DNA-electrochemical biosensor
    Bruzaca, Evellin Enny S.
    Lopes, Ilanna C.
    Silva, Elizaura Hyeda C.
    Carvalho, Paulina Andrea V.
    Tanaka, Auro A.
    MICROCHEMICAL JOURNAL, 2017, 133 : 81 - 89
  • [28] Electrochemical behaviors of DNA at mercury film electrode
    Wu, JT
    Huang, Y
    Zhou, JZ
    Luo, J
    Lin, ZH
    BIOELECTROCHEMISTRY AND BIOENERGETICS, 1997, 44 (01): : 151 - 154
  • [29] Interaction of nicotine and its pharmaceutical derivatives with acrylamide/itaconic acid hydrogels
    Karadag, E
    Saraydin, D
    Guven, O
    JOURNAL OF APPLIED POLYMER SCIENCE, 1997, 66 (04) : 733 - 739
  • [30] Electrochemical behaviour of anticancer drug lomustine and in situ evaluation of its interaction with DNA
    de Carvalho, Paulina Andrea, V
    Lopes, Ilanna Campelo
    Silva, Elizaura Hyeda C.
    Bruzaca, Evellin Enny S.
    Alves, Hugo Jose
    Lima, Mayara Ingrid S.
    Tanaka, Auro Atsushi
    JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2019, 176
12345