Multicomponent drug efflux complexes: architecture and mechanism of assembly

被引：38

作者：

Zgurskaya, Helen I. ^{[1
]}

机构：

[1] Univ Oklahoma, Dept Chem & Biochem, Norman, OK 73019 USA

来源：

FUTURE MICROBIOLOGY | 2009年 / 4卷 / 07期

关键词：

antibiotic resistance; membrane fusion protein; multidrug efflux transporter; TolC; GRAM-NEGATIVE BACTERIA; MEMBRANE-FUSION PROTEIN; MAJOR FACILITATOR SUPERFAMILY; MULTIDRUG TRANSPORTER MDFA; LARGE PERIPLASMIC LOOPS; ESCHERICHIA-COLI; PSEUDOMONAS-AERUGINOSA; CRYSTAL-STRUCTURE; ABC TRANSPORTER; SUBSTRATE-SPECIFICITY;

D O I：

10.2217/FMB.09.62

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Multidrug efflux pumps are major contributors to intrinsic antibiotic resistance in Gram-negative pathogens. The basic structure of these pumps comprises an inner membrane transporter, a periplasmic membrane fusion protein and an outer membrane channel. However, the architecture and composition of multidrug efflux complexes vary significantly because of the topological and functional diversity of the inner membrane transporters, This article presents the current views on architecture and assembly of multicomponent drug efflux transporters from Gram-negative bacteria.

引用

页码：919 / 932

页数：14

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