Breaking proteins with mutations: threads and thresholds in evolution

被引：32
作者：
Bloom, Jesse D. [1 ]
Arnold, Frances H.
Wilke, Claus O.
机构：
[1] CALTECH, Div Chem & Chem Engn, Pasadena, CA 91125 USA
[2] Univ Texas, Sect Integrat Biol, Austin, TX 78712 USA
[3] Univ Texas, Ctr Computat Biol & Bioinformat, Austin, TX 78712 USA
来源：
MOLECULAR SYSTEMS BIOLOGY | 2007年 / 3卷 / 1期
关键词：
D O I：
10.1038/msb4100119
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
引用
收藏
页数：2
相关论文
共 7 条
  • [1] Robustness-epistasis link shapes the fitness landscape of a randomly drifting protein
    Bershtein, Shimon
    Segal, Michal
    Bekerman, Roy
    Tokuriki, Nobuhiko
    Tawfik, Dan S.
    [J]. NATURE, 2006, 444 (7121) : 929 - 932
  • [2] Protein stability promotes evolvability
    Bloom, JD
    Labthavikul, ST
    Otey, CR
    Arnold, FH
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (15) : 5869 - 5874
  • [3] Thermodynamic prediction of protein neutrality
    Bloom, JD
    Silberg, JJ
    Wilke, CO
    Drummond, DA
    Adami, C
    Arnold, FH
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (03) : 606 - 611
  • [4] MUTATION-SELECTION BALANCE AND THE EVOLUTIONARY ADVANTAGE OF SEX AND RECOMBINATION
    CHARLESWORTH, B
    [J]. GENETICS RESEARCH, 1990, 55 (03) : 199 - 221
  • [5] Protein tolerance to random amino acid change
    Guo, HH
    Choe, J
    Loeb, LA
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (25) : 9205 - 9210
  • [6] Generation of large libraries of random mutants in Bacillus subtilis by PCR-based plasmid multimerization
    Shafikhani, S
    Siegel, RA
    Ferrari, E
    Schellenberger, V
    [J]. BIOTECHNIQUES, 1997, 23 (02) : 304 - 310
  • [7] Predicting the tolerance of proteins to random amino acid substitution
    Wilke, CO
    Bloom, JD
    Drummond, DA
    Raval, A
    [J]. BIOPHYSICAL JOURNAL, 2005, 89 (06) : 3714 - 3720
1