Basal-like breast cancer: A review

被引：4

作者：

Treilleux, Isabelle ^{[1
]}

Morellon-Mialhe, Blandine ^{[1
]}

机构：

[1] Ctr Leon Berard, Serv Anat Pathol, F-69373 Lyon 08, France

来源：

ANNALES DE PATHOLOGIE | 2009年 / 29卷 / 03期

关键词：

Breast cancer; Basal phenotype; Basal cytokeratins; Myoepithelial markers; Immunohistochemistry; Prognosis; IN-SITU HYBRIDIZATION; DUCTAL CARCINOMA; EPITHELIAL PHENOTYPE; EXPRESSION; SUBTYPE; AMPLIFICATION; MUTATIONS; RECEPTOR; MARKERS; EGFR;

D O I：

10.1016/j.annpat.2009.04.001

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Breast cancers of basal phenotype have been identified by molecular profiting and are associated with a poor prognosis. This review describes the morphological characteristics of these tumors and focuses on their profiting using immunohistochemistry: absence of detectable hormone receptors and HER2, expression of basal cytokeratins (CK5/6, CK14), myoepithelial markers (p63, smooth muscle actin) and HER1. This phenotype may be encountered in all histological types of breast cancer and is further divided into three subtypes according to prognosis and protein profiting. Pure basal and basal/myoepithelial subtypes have a poor prognosis in contrast to the myoepithelial subtype. (C) 2009 Elsevier Masson SAS. All rights reserved.

引用

页码：180 / 186

页数：7

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