Chronic administration of cyclosporine A does not impair memory retention in rats

被引：8

作者：

Borlongan, CV ^{[1
]}

Fujisaki, T ^{[1
]}

Watanabe, S ^{[1
]}

机构：

[1] KEIO UNIV,DEPT PSYCHOL,MINATO KU,TOKYO 108,JAPAN

来源：

NEUROREPORT | 1997年 / 8卷 / 03期

关键词：

cyclosporine A; immunosuppression; memory retention; neuroprotection; passive avoidance;

D O I：

10.1097/00001756-199702100-00019

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

CYCLOSPORINE A (CsA) is the treatment of choice for patients undergoing organ as well as neural transplantation. CsA immunosuppression is associated with neurological and motor alterations in transplant recipients as well as in normal or hemiparkinsonian rats. We investigated possible impairments of memory retention in CsA-treated rats to determine direct effects of CsA on the dementing illness inherent in most neurodegenerative disorders. Rats receiving chronic treatment with CsA at a dose of 10 mg kg(-1), i.p., daily for 26 days, as used in neural transplants for animal models of neurodegenerative disorders, did not significantly differ from vehicle-treated rats, and even appeared slightly improved, in retention of a passive avoidance task. This present observation parallels recent studies demonstrating 'neuroprotective' effects of CsA in addition to its immunosuppressive effects.

引用

页码：673 / 676

页数：4

共 24 条

[1] Cyclosporine inhibition of leukocyte calcineurin is much less in whole blood than in culture medium [J].