Alcohol intake and colorectal cancer risk: A dose-response meta-analysis of published cohort studies

被引:152
作者
Moskal, Aurelie
Norat, Teresa
Ferrari, Pietro
Riboli, Elio
机构
[1] Int Agcy Res Canc, Nutr & Hormones Grp, F-69372 Lyon, France
[2] Univ London Imperial Coll Sci Technol & Med, Dept Epidemiol & Publ Hlth, London, England
关键词
alcohol; colorectal cancer; meta-analysis; cohort; dose-response; alcohol intake (instead of alcohol); colon; rectum;
D O I
10.1002/ijc.22299
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The epidemiologic evidence support that alcohol intake might be associated with increased colorectal cancer risk. However, the results by anatomic site in the large bowel are inconsistent. We conducted a meta-analysis of prospective cohort studies published between 1990 and June 2005 on the relationship between alcohol intake and colon and rectal cancer. We quantified associations with colon and rectal cancer using meta-analysis of relative risk (RR) associated to the highest versus the lowest category of alcohol intake and meta-analysis of study-specific dose-response slopes using fixed or random effect models depending on the heterogeneity of effects among studies. Sixteen prospective cohort studies including more than 6,300 patients with colorectal cancer were eligible for inclusion. High alcohol intake was significantly associated with increased risk of colon (RR = 1.50; 95% CI = 1.25, 1.79) and rectal cancer (RR = 1.63; 95% CI = 1.35, 1.97) when comparing the highest with the lowest category of alcohol intake, equivalent to a 15% increase of risk of colon or rectal cancer for an increase of 100 g of alcohol intake per week. The relationship did not differ significantly by anatomical site (colon, rectum). Using meta-regression analysis, we identified geographical area where the study was conducted as a possible source of between-study heterogeneity of effects among studies. Lifestyle recommendations for prevention of colorectal cancer should consider limiting alcohol intake. (c) 2006 Wiley-Liss, Inc.
引用
收藏
页码:664 / 671
页数:8
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