Selective N-3- and 5'-O-alkylation of 2',3'-O-isopropylideneuridine with methyl iodide

被引：10

作者：

Hovinen, J

机构：

[1] Department of Chemistry, University of Turku

来源：

HELVETICA CHIMICA ACTA | 1997年 / 80卷 / 03期

关键词：

D O I：

10.1002/hlca.19970800319

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The 2',3'-O-isopropylideneuridine (1) reacts with MeI in the presence of an excess of NaH in THF giving 2',3'-O-isopropylidene-5'-O-methyluridine (2). Prolonged reaction time gives rise to 2',3'-O-isopropylidene-3,5'-O-dimethyluridine (4). The use of an equimolar amount of base and alkylating agent results predominantly in methylation at N(3) (--> 3).

引用

页码：851 / 855

页数：5

共 25 条

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