CsOH/γ-Al2O3: a heterogeneous reusable basic catalyst for one-pot synthesis of 2-amino-4,6-diaryl pyrimidines

被引：21

作者：

Nimkar, Amey ^{[1
]}

Ramana, M. M. V. ^{[1
]}

Betkar, Rahul ^{[1
]}

Ranade, Prasanna ^{[1
]}

Mundhe, Balaji ^{[1
]}

机构：

[1] Univ Bombay, Dept Chem, Bombay 400098, Maharashtra, India

来源：

NEW JOURNAL OF CHEMISTRY | 2016年 / 40卷 / 03期

关键词：

EFFICIENT METHOD; DERIVATIVES; THERAPY; SOLVENT; ANALOGS; ALUMINA;

D O I：

10.1039/c5nj03565a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new strategy for a one-pot synthesis of 2-amino-4, 6-diaryl pyrimidines using CsOH/gamma-Al2O3 as a heterogeneous, reusable basic catalyst is presented. The developed synthetic protocol for pyrimidines is a one-pot three-component reaction of acetophenone, aromatic aldehydes and guanidine hydrochloride in ethanol. Characterization of the catalyst CsOH/gamma-Al2O3 was performed by using FT-IR, XRD, TG-DTA, SEM, BET surface area and CO2-TPD analysis techniques. The analytical data prove that the catalyst has excellent reusability and also indicate their good thermal stability.

引用

页码：2541 / 2546

页数：6

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