Novel loci and pathways significantly associated with longevity

被引：139

作者：

Zeng, Yi ^{[1
,2
,3
]}

Nie, Chao ^{[4
]}

Min, Junxia ^{[5
]}

Liu, Xiaomin ^{[4
]}

Li, Mengmeng ^{[6
]}

Chen, Huashuai ^{[1
,2
,7
]}

Xu, Hanshi ^{[4
]}

Wang, Mingbang ^{[4
]}

Ni, Ting ^{[8
,9
]}

Li, Yang ^{[10
]}

Yan, Han ^{[10
]}

Zhang, Jin-Pei ^{[10
]}

Song, Chun ^{[10
]}

Chi, Li-Qing ^{[10
]}

Wang, Han-Ming ^{[10
]}

Dong, Jie ^{[10
]}

Zheng, Gu-Yan ^{[10
]}

Lin, Li ^{[6
]}

Qian, Feng ^{[6
]}

Qi, Yanwei ^{[4
,11
]}

Liu, Xiao ^{[4
]}

Cao, Hongzhi ^{[4
]}

Wang, Yinghao ^{[4
]}

Zhang, Lijuan ^{[4
]}

Li, Zhaochun ^{[4
]}

Zhou, Yufeng ^{[4
]}

Wang, Yan ^{[4
]}

Lu, Jiehua ^{[12
]}

Li, Jianxin ^{[12
]}

Qi, Ming ^{[5
]}

Bolund, Lars ^{[4
,13
]}

Yashin, Anatoliy ^{[14
]}

Land, Kenneth C. ^{[14
]}

Gregory, Simon ^{[15
]}

Yang, Ze ^{[16
]}

Gottschalk, William ^{[17
]}

Tao, Wei ^{[18
]}

Wang, Jian ^{[4
,19
]}

Wang, Jun ^{[4
,20
]}

Xu, Xun ^{[4
]}

Bae, Harold ^{[21
]}

Nygaard, Marianne ^{[22
]}

Christiansen, Lene ^{[22
]}

Christensen, Kaare ^{[22
]}

Franceschi, Claudio ^{[23
,24
]}

Lutz, Michael W. ^{[17
]}

Gu, Jun ^{[18
]}

Tan, Qihua ^{[22
]}

Perls, Thomas ^{[25
]}

Sebastiani, Paola ^{[26
]}

机构：

[1] Duke Univ, Ctr Study Aging & Human Dev, Durham, NC USA

[2] Duke Univ, Sch Med, Div Geriatr, Durham, NC USA

[3] Peking Univ, Ctr Healthy Aging & Dev Studies, Natl Sch Dev, Beijing 100871, Peoples R China

[4] BGI Shenzhen, Shenzhen, Peoples R China

[5] Zhejiang Univ, Sch Med, Affiliated Hosp 1, Inst Translat Med, Hangzhou 310003, Zhejiang, Peoples R China

[6] Second Mil Med Univ, Dept Rheumatol & Immunol, Shanghai Changzheng Hosp, Shanghai, Peoples R China

[7] Xiangtan Univ, Business Sch, Xiangtan, Peoples R China

[8] Fudan Univ, State Key Lab Genet Engn, Shanghai 200433, Peoples R China

[9] Fudan Univ, MOE Key Lab Contemporary Anthropol, Sch Life Sci, Shanghai 200433, Peoples R China

[10] Peking Univ, Dept Human Populat Genet, Inst Mol Med, Beijing 100871, Peoples R China

[11] Anhui Med Univ, Dept Biomed Engn, Sch Life Sci, Hefei, Peoples R China

[12] Peking Univ, Dept Sociol, Beijing 100871, Peoples R China

[13] Aarhus Univ, Dept Biomed, Aarhus, Denmark

[14] Duke Univ, Populat Res Inst, Durham, NC USA

[15] Duke Univ, Med Ctr, Duke Mol Physiol Inst, Durham, NC USA

[16] Beijing Hosp, Natl Inst Geriatr, Minist Hlth, Beijing, Peoples R China

[17] Duke Univ, Med Ctr, Dept Neurol, Durham, NC USA

[18] Peking Univ, Sch Life Sci, Beijing 100871, Peoples R China

[19] James D Watson Inst Genome Sci, Hangzhou, Zhejiang, Peoples R China

[20] Univ Copenhagen, Dept Biol, Copenhagen, Denmark

[21] Oregon State Univ, Coll Publ Hlth & Human Sci, Corvallis, OR 97331 USA

[22] Univ Southern Denmark, Danish Aging Res Ctr, Unit Epidemiol Biostat & Biodemog, Inst Publ Hlth, Odense, Denmark

[23] Univ Bologna, Dept Expt Diagnost & Specialty Med, Bologna, Italy

[24] Univ Bologna, Interdept Ctr L Galvani, Bologna, Italy

[25] Boston Univ, Sch Med, Geriatr Sect, Dept Med, Boston, MA 02118 USA

[26] Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA USA

[27] Leiden Univ, Med Ctr, Dept Mol Epidemiol & Netherlands Consortium Healt, Leiden, Netherlands

[28] Max Planck Inst Demog Res, Rostock, Germany

来源：

SCIENTIFIC REPORTS | 2016年 / 6卷

基金：

中国国家自然科学基金;

关键词：

GENOME-WIDE ASSOCIATION; LIFE-SPAN; FOXO GENOTYPES; ADVANCED AGES; HAN CHINESE; METAANALYSIS; MORTALITY; SURVIVAL; HEALTH; OLDER;

D O I：

10.1038/srep21243

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Only two genome-wide significant loci associated with longevity have been identified so far, probably because of insufficient sample sizes of centenarians, whose genomes may harbor genetic variants associated with health and longevity. Here we report a genome-wide association study (GWAS) of Han Chinese with a sample size 2.7 times the largest previously published GWAS on centenarians. We identified 11 independent loci associated with longevity replicated in Southern-Northern regions of China, including two novel loci (rs2069837-IL6; rs2440012-ANKRD20A9P) with genomewide significance and the rest with suggestive significance (P < 3.65 x 10(-5)). Eight independent SNPs overlapped across Han Chinese, European and U.S. populations, and APOE and 5q33.3 were replicated as longevity loci. Integrated analysis indicates four pathways (starch, sucrose and xenobiotic

引用

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