Ferroptosis becomes immunogenic: implications for anticancer treatments

被引：72

作者：

Tang, Daolin ^{[1
]}

Kepp, Oliver ^{[2
,3
]}

Kroemer, Guido ^{[2
,3
,4
,5
,6
]}

机构：

[1] Univ Texas Southwestern Med Ctr Dallas, Dept Surg, Dallas, TX 75390 USA

[2] Univ Paris, Sorbonne Univ, Ctr Rech Cordeliers, Equipe Labellisee Ligue Canc,INSERM,U1138, F-75006 Paris, France

[3] Gustave Roussy Canc Campus, Metabol & Cell Biol Platforms, F-94800 Villejuif, France

[4] Hop Europeen Georges Pompidou, Pole Biol, Paris, France

[5] Chinese Acad Sci, Suzhou Inst Syst Biol, Suzhou, Peoples R China

[6] Karolinska Univ Hosp, Dept Womens & Childrens Hlth, Stockholm, Sweden

来源：

ONCOIMMUNOLOGY | 2021年 / 10卷 / 01期

关键词：

Damage-associated molecular pattern; dendritic cells; anticancer vaccination;

D O I：

10.1080/2162402X.2020.1862949

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Ferroptosis is an iron-dependent form of non-apoptotic cell death that has recently been attributed with antitumor immune effects. Thus, early ferroptotic cells underwent immunogenic cell death that was accompanied by the emission of damage-associated molecular patterns (DAMPs) and triggered dendritic cell maturation in vitro. Furthermore, ferroptotic cells were able to vaccinate against a rechallenge with fibrosarcoma in preclinical models.

引用

页数：2

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