Evaluation of antiviral effect and toxicity of total flavonoids extracted from Robinia pseudoacacia cv. idaho

被引：18

作者：

Guo, Hao ^{[1
]}

Wan, Xinhuan ^{[1
]}

Niu, Fengju ^{[2
]}

Sun, Jujie ^{[3
]}

Shi, Chenxiao ^{[1
]}

Ye, Jessica Meng ^{[4
]}

Zhou, Changzheng ^{[1
]}

机构：

[1] Shandong Univ Tradit Chinese Med, Sch Pharm, Jinan, Shandong, Peoples R China

[2] Dept Shandong Inst Tradit Chinese Med, Jinan, Shandong, Peoples R China

[3] Shandong First Med Univ & Shandong Acad Med Sci, Shandong Canc Hosp & Inst, Tai An, Shandong, Peoples R China

[4] Univ British Columbia, Sch Land & Food Syst, Vancouver, BC, Canada

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2019年 / 118卷

关键词：

Robinia pseudoacacia cv. idaho; Total flavonoids; Antiviral effect; Toxicity; CHOLESTEROL-METABOLISM;

D O I：

10.1016/j.biopha.2019.109335

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

In this study, we aimed to evaluate the antiviral effect of total flavonoids extracted from Robinia pseudoacacia cv. idaho (RPTF) in vivo and its toxicity on rats with oral gavage. RPTF was prepared by percolation with 70% ethanol for 24 h and its antiviral effect on different kinds of viruses was evaluated in vitro by MTT staining. The long-term toxicity of RPTF on rats was evaluated through the detection of general behavior, body weight, food intake and related organ tissue sections of experimental animals. We found that RPTF produced significantly inhibitory effects on HSV-1 and EV-71 viruses with the therapeutic index TI values 113.8 and 46.2, respectively. Moreover, toxicity evaluation in vivo showed no significantly adverse effects in rats, indicating that RPTF was safe in use. In conclusion, we demonstrated that RPTF, natural compounds in the Chinese traditional medicine, could act as promising and effective antiviral therapeutics with relative safety in use.

引用

页数：8

共 28 条

[1] Isolation of Antiosteoporotic Compounds from Seeds of Sophora japonica [J].

Abdallah, Hossam M. ;

Al-Abd, Ahmed M. ;

Asaad, Gihan F. ;

Abdel-Naim, Ashraf B. ;

El-Halawany, Ali M. .

PLOS ONE, 2014, 9 (06)

[2]

AKHMEDKHODZHAEVA N M, 1983, Chemistry of Natural Compounds (English Translation of Khimiya Prirodnykh Soedinenii), V19, P116, DOI 10.1007/BF00579994

[3] The Role of LAT in Increased CD8+ T Cell Exhaustion in Trigeminal Ganglia of Mice Latently Infected with Herpes Simplex Virus 1 [J].

Allen, Sariah J. ;

Hamrah, Pedram ;

Gate, David ;

Mott, Kevin R. ;

Mantopoulos, Dimosthenis ;

Zheng, Lixin ;

Town, Terrence ;

Jones, Clinton ;

von Andrian, Ulrich H. ;

Freeman, Gordon J. ;

Sharpe, Arlene H. ;

BenMohamed, Lbachir ;

Ahmed, Rafi ;

Wechsler, Steven L. ;

Ghiasi, Homayon .

JOURNAL OF VIROLOGY, 2011, 85 (09) :4184-4197

[4] Safety of zidovudine/lamivudine scored tablets in children with HIV infection in Europe and Thailand [J].

Bailey, Heather ;

Thompson, Lindsay ;

Childs, Tristan ;

Collins, Intira Jeannie ;

Tostevin, Anna ;

Goodall, Ruth ;

Goetghebuer, Tessa ;

Spoulou, Vana ;

Galli, Luisa ;

Marczynska, Magda ;

Marques, Laura ;

Ene, Luminita ;

Samarina, Anna ;

Rosenberg, Vladimir ;

Dodonov, Konstantin ;

Okhonskaia, Liubov ;

Noguera Julian, Antoni ;

Rojo Conejo, Pablo ;

Ramos Amador, Jose Tomas ;

Naver, Lars ;

Jourdain, Gonzague ;

Thorne, Claire ;

Giaquinto, Carlo ;

Judd, Ali .

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 2017, 73 (04) :463-468

[5] HLA-A*0201-restricted CD8+ cytotoxic T lymphocyte epitopes identified trom herpes simplex virus glycoprotein D [J].

Chentoufi, Aziz Alami ;

Zhang, Xiuli ;

Lamberth, Kasper ;

Dasgupta, Gargi ;

Bettahi, Ilham ;

Nguyen, Alex ;

Wu, Michelle ;

Zhu, Xiaoming ;

Mohebbi, Amir ;

Buus, Soren ;

Wechsler, Steven L. ;

Nesburn, Anthony B. ;

BenMohamed, Lbachir .

JOURNAL OF IMMUNOLOGY, 2008, 180 (01) :426-437

[6] Review of Enterovirus 71 Vaccines [J].

Chong, Pele ;

Liu, Chia-Chyi ;

Chow, Yen-Hung ;

Chou, Ai-Hsiang ;

Klein, Michel .

CLINICAL INFECTIOUS DISEASES, 2015, 60 (05) :797-803

[7] REGULATION OF CHOLESTEROL-METABOLISM IN THE INTESTINE [J].

FIELD, FJ ;

KAM, NTP ;

MATHUR, SN .

GASTROENTEROLOGY, 1990, 99 (02) :539-551

[8] Foraging choices balanced between resource abundance and handling concerns: how the honeybee, Apis mellifera, select the flowers of Robinia pseudoacacia [J].

Giovanetti, M. .

BULLETIN OF ENTOMOLOGICAL RESEARCH, 2019, 109 (03) :316-324

[9] Local and traditional uses, phytochemistry, and pharmacology of Sophora japonica L.: A review [J].

He, Xirui ;

Bai, Yajun ;

Zhao, Zefeng ;

Wang, Xiaoxiao ;

Fang, Jiacheng ;

Huang, Linhong ;

Zeng, Min ;

Zhang, Qiang ;

Zhang, Yajun ;

Zheng, Xiaohui .

JOURNAL OF ETHNOPHARMACOLOGY, 2016, 187 :160-182

[10] Differential roles of migratory and resident DCs in T cell priming after mucosal or skin HSV-1 infection [J].

Lee, Heung Kyu ;

Zamora, Melodie ;

Linehan, Melissa M. ;

Iijima, Norifumi ;

Gonzalez, David ;

Haberman, Ann ;

Iwasaki, Akiko .

JOURNAL OF EXPERIMENTAL MEDICINE, 2009, 206 (02) :359-370

← 1 2 3 →