Association of the Pro12Ala polymorphism in peroxisome proliferator-activated receptor γ2 with decreased basic metabolic rate in women with polycystic ovary syndrome
Objective: The peroxisome proliferator-activated receptor (PTAR)gamma is a transcription Factor involved in glucose homeostasis and energy metabolism. A missense mutation at codon 12 in the PPAR gamma 2 has been associated with increased body mass index (BMI) and attenuated insulin resistance (IR) in polycystic ovary syndrome (PCOS). We have recently shown it decreased basic metabolic rate (BMR) ill PCOS. The aim Of the Present study is to determine the prevalence of the Pro12Ala polymorphism of the PPAR gamma 2 gene and its associations with indices of IR and BMR ill lean and slightly overweight PCOS women. Design: Case-control association study involving 156 PCOS women with biochemical hyperandrogenism, chronic anovulation and polycystic ovarian morphology in ultrasound and 56 unrelated healthy controls. Methods: Hormonal determinations were performed by electrochemiluninescence quantitation or RIA BMR was measured by indirect calorimetry All Subjects were genotyped by a PCR-restriction fragment length polymorphism assay. Results: Genotype frequencies of the Pro12Ala polymorphism in PPAR gamma 2 did not: differ among PCOS women and control subjects. The presence of Pro12Ala polymorphism of PPAR gamma 2 was associated with lower BMR (P=0.04). This finding was valid in Our Subgroup of lean PCOS (BMI < 2 5 kg/m(2)). ill which the Ala variant was also associated with higher total testosterone values. Conclusion: The Pro12Ala polymorphism in the PPAR gamma 2 gene is associated with decreased BMR in women with PCOS and biochemical hyper-androgenemia. These young women are therefore at risk to increase their body weight and should restrict their energy intake by diet and enhance their energy expenditure by exercise.
机构:
Univ Sultan Zainal Abidin UniSZA, Fac Hlth Sci, Gong Badak Campus, Kuala Terengganu 21300, Terengganu Daru, MalaysiaUniv Sultan Zainal Abidin UniSZA, Fac Hlth Sci, Gong Badak Campus, Kuala Terengganu 21300, Terengganu Daru, Malaysia
Zahri, Mohd Khairi
Emilia, Apidi
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Univ Sultan Zainal Abidin UniSZA, Fac Med, Med Campus,Jalan Sultan Mahmud, Kuala Terengganu 20400, Terengganu Daru, MalaysiaUniv Sultan Zainal Abidin UniSZA, Fac Hlth Sci, Gong Badak Campus, Kuala Terengganu 21300, Terengganu Daru, Malaysia
Emilia, Apidi
Rawi, Rohayu Izanwati Mohd
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Univ Sultan Zainal Abidin UniSZA, Fac Hlth Sci, Gong Badak Campus, Kuala Terengganu 21300, Terengganu Daru, MalaysiaUniv Sultan Zainal Abidin UniSZA, Fac Hlth Sci, Gong Badak Campus, Kuala Terengganu 21300, Terengganu Daru, Malaysia
Rawi, Rohayu Izanwati Mohd
Taib, Wan Rohani Wan
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Univ Sultan Zainal Abidin UniSZA, Fac Hlth Sci, Gong Badak Campus, Kuala Terengganu 21300, Terengganu Daru, MalaysiaUniv Sultan Zainal Abidin UniSZA, Fac Hlth Sci, Gong Badak Campus, Kuala Terengganu 21300, Terengganu Daru, Malaysia
Taib, Wan Rohani Wan
Sani, Aliya Irshad
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Univ Sultan Zainal Abidin UniSZA, Fac Med, Med Campus,Jalan Sultan Mahmud, Kuala Terengganu 20400, Terengganu Daru, MalaysiaUniv Sultan Zainal Abidin UniSZA, Fac Hlth Sci, Gong Badak Campus, Kuala Terengganu 21300, Terengganu Daru, Malaysia
Sani, Aliya Irshad
Baig, Atif Amin
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Univ Sultan Zainal Abidin UniSZA, Fac Med, Med Campus,Jalan Sultan Mahmud, Kuala Terengganu 20400, Terengganu Daru, MalaysiaUniv Sultan Zainal Abidin UniSZA, Fac Hlth Sci, Gong Badak Campus, Kuala Terengganu 21300, Terengganu Daru, Malaysia
机构:
Sungkyunkwan Univ, Sch Med, Dept Endocrinol & Metab, Seoul 135710, South KoreaSungkyunkwan Univ, Sch Med, Dept Endocrinol & Metab, Seoul 135710, South Korea
Rhee, Eun-Jung
Oh, Ki-Won
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Sungkyunkwan Univ, Sch Med, Dept Endocrinol & Metab, Seoul 135710, South KoreaSungkyunkwan Univ, Sch Med, Dept Endocrinol & Metab, Seoul 135710, South Korea
Oh, Ki-Won
Yun, Eun-Joo
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h-index: 0
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Hallym Univ, Dept Radiol, Seoul 134701, South KoreaSungkyunkwan Univ, Sch Med, Dept Endocrinol & Metab, Seoul 135710, South Korea
Yun, Eun-Joo
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Jung, Chan-Hee
Park, Cheol-Young
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Sungkyunkwan Univ, Sch Med, Dept Endocrinol & Metab, Seoul 135710, South KoreaSungkyunkwan Univ, Sch Med, Dept Endocrinol & Metab, Seoul 135710, South Korea
Park, Cheol-Young
Lee, Won-Young
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Sungkyunkwan Univ, Sch Med, Dept Endocrinol & Metab, Seoul 135710, South KoreaSungkyunkwan Univ, Sch Med, Dept Endocrinol & Metab, Seoul 135710, South Korea
Lee, Won-Young
Oh, Eun-Sook
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Miz Medi Hosp, Dept Endocrinol & Metab, Seoul 157280, South KoreaSungkyunkwan Univ, Sch Med, Dept Endocrinol & Metab, Seoul 135710, South Korea
Oh, Eun-Sook
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Baek, Ki-Hyun
Kang, Moo-Il
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Catholic Univ Korea, Coll Med, Dept Endocrinol & Metab, Seoul 137701, South KoreaSungkyunkwan Univ, Sch Med, Dept Endocrinol & Metab, Seoul 135710, South Korea
Kang, Moo-Il
Park, Sung-Woo
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Sungkyunkwan Univ, Sch Med, Dept Endocrinol & Metab, Seoul 135710, South KoreaSungkyunkwan Univ, Sch Med, Dept Endocrinol & Metab, Seoul 135710, South Korea
Park, Sung-Woo
Kim, Sun-Woo
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Sungkyunkwan Univ, Sch Med, Dept Endocrinol & Metab, Seoul 135710, South KoreaSungkyunkwan Univ, Sch Med, Dept Endocrinol & Metab, Seoul 135710, South Korea
机构:
Dalian Med Univ, Affiliated Hosp 1, Dept Gastroenterol, Dalian, Peoples R ChinaDalian Med Univ, Affiliated Hosp 1, Dept Gastroenterol, Dalian, Peoples R China
Zhang, Zhi-Feng
Yang, Ning
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h-index: 0
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Dalian Med Univ, Affiliated Hosp 1, Dept Nephrol, Dalian, Peoples R ChinaDalian Med Univ, Affiliated Hosp 1, Dept Gastroenterol, Dalian, Peoples R China
Yang, Ning
Zhao, Gang
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Dalian Med Univ, Affiliated Hosp 1, Dept Gastroenterol, Dalian, Peoples R ChinaDalian Med Univ, Affiliated Hosp 1, Dept Gastroenterol, Dalian, Peoples R China
Zhao, Gang
Zhu, Lei
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Dalian Med Univ, Affiliated Hosp 1, Dept Gastroenterol, Dalian, Peoples R ChinaDalian Med Univ, Affiliated Hosp 1, Dept Gastroenterol, Dalian, Peoples R China
Zhu, Lei
Wang, Li-Xia
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Dalian Med Univ, Affiliated Hosp 1, Dept Gastroenterol, Dalian, Peoples R ChinaDalian Med Univ, Affiliated Hosp 1, Dept Gastroenterol, Dalian, Peoples R China
机构:
Sun Yat Sen Univ, Dept Nephrol, Affiliated Hosp 6, Guangzhou 510655, Guangdong, Peoples R ChinaSun Yat Sen Univ, Dept Nephrol, Affiliated Hosp 6, Guangzhou 510655, Guangdong, Peoples R China
Zhou, Tian-Biao
Guo, Xue-Feng
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Sun Yat Sen Univ, Dept Colorectal Surg, Affiliated Hosp 6, Guangzhou 510655, Guangdong, Peoples R ChinaSun Yat Sen Univ, Dept Nephrol, Affiliated Hosp 6, Guangzhou 510655, Guangdong, Peoples R China
Guo, Xue-Feng
Yin, Sheng-Sheng
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Sun Yat Sen Univ, Dept Sci Grad, Affiliated Hosp 6, Guangzhou 510655, Guangdong, Peoples R ChinaSun Yat Sen Univ, Dept Nephrol, Affiliated Hosp 6, Guangzhou 510655, Guangdong, Peoples R China
机构:
Univ Sultan Zainal Abidin UniSZA, Fac Hlth Sci, Gong Badak Campus, Kuala Terengganu 21300, Terengganu Daru, MalaysiaUniv Sultan Zainal Abidin UniSZA, Fac Hlth Sci, Gong Badak Campus, Kuala Terengganu 21300, Terengganu Daru, Malaysia
Zahri, Mohd Khairi
Emilia, Apidi
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h-index: 0
机构:
Univ Sultan Zainal Abidin UniSZA, Fac Med, Med Campus,Jalan Sultan Mahmud, Kuala Terengganu 20400, Terengganu Daru, MalaysiaUniv Sultan Zainal Abidin UniSZA, Fac Hlth Sci, Gong Badak Campus, Kuala Terengganu 21300, Terengganu Daru, Malaysia
Emilia, Apidi
Rawi, Rohayu Izanwati Mohd
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h-index: 0
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Univ Sultan Zainal Abidin UniSZA, Fac Hlth Sci, Gong Badak Campus, Kuala Terengganu 21300, Terengganu Daru, MalaysiaUniv Sultan Zainal Abidin UniSZA, Fac Hlth Sci, Gong Badak Campus, Kuala Terengganu 21300, Terengganu Daru, Malaysia
Rawi, Rohayu Izanwati Mohd
Taib, Wan Rohani Wan
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Univ Sultan Zainal Abidin UniSZA, Fac Hlth Sci, Gong Badak Campus, Kuala Terengganu 21300, Terengganu Daru, MalaysiaUniv Sultan Zainal Abidin UniSZA, Fac Hlth Sci, Gong Badak Campus, Kuala Terengganu 21300, Terengganu Daru, Malaysia
Taib, Wan Rohani Wan
Sani, Aliya Irshad
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Univ Sultan Zainal Abidin UniSZA, Fac Med, Med Campus,Jalan Sultan Mahmud, Kuala Terengganu 20400, Terengganu Daru, MalaysiaUniv Sultan Zainal Abidin UniSZA, Fac Hlth Sci, Gong Badak Campus, Kuala Terengganu 21300, Terengganu Daru, Malaysia
Sani, Aliya Irshad
Baig, Atif Amin
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Univ Sultan Zainal Abidin UniSZA, Fac Med, Med Campus,Jalan Sultan Mahmud, Kuala Terengganu 20400, Terengganu Daru, MalaysiaUniv Sultan Zainal Abidin UniSZA, Fac Hlth Sci, Gong Badak Campus, Kuala Terengganu 21300, Terengganu Daru, Malaysia
机构:
Sungkyunkwan Univ, Sch Med, Dept Endocrinol & Metab, Seoul 135710, South KoreaSungkyunkwan Univ, Sch Med, Dept Endocrinol & Metab, Seoul 135710, South Korea
Rhee, Eun-Jung
Oh, Ki-Won
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h-index: 0
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Sungkyunkwan Univ, Sch Med, Dept Endocrinol & Metab, Seoul 135710, South KoreaSungkyunkwan Univ, Sch Med, Dept Endocrinol & Metab, Seoul 135710, South Korea
Oh, Ki-Won
Yun, Eun-Joo
论文数: 0引用数: 0
h-index: 0
机构:
Hallym Univ, Dept Radiol, Seoul 134701, South KoreaSungkyunkwan Univ, Sch Med, Dept Endocrinol & Metab, Seoul 135710, South Korea
Yun, Eun-Joo
论文数: 引用数:
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机构:
Jung, Chan-Hee
Park, Cheol-Young
论文数: 0引用数: 0
h-index: 0
机构:
Sungkyunkwan Univ, Sch Med, Dept Endocrinol & Metab, Seoul 135710, South KoreaSungkyunkwan Univ, Sch Med, Dept Endocrinol & Metab, Seoul 135710, South Korea
Park, Cheol-Young
Lee, Won-Young
论文数: 0引用数: 0
h-index: 0
机构:
Sungkyunkwan Univ, Sch Med, Dept Endocrinol & Metab, Seoul 135710, South KoreaSungkyunkwan Univ, Sch Med, Dept Endocrinol & Metab, Seoul 135710, South Korea
Lee, Won-Young
Oh, Eun-Sook
论文数: 0引用数: 0
h-index: 0
机构:
Miz Medi Hosp, Dept Endocrinol & Metab, Seoul 157280, South KoreaSungkyunkwan Univ, Sch Med, Dept Endocrinol & Metab, Seoul 135710, South Korea
Oh, Eun-Sook
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机构:
Baek, Ki-Hyun
Kang, Moo-Il
论文数: 0引用数: 0
h-index: 0
机构:
Catholic Univ Korea, Coll Med, Dept Endocrinol & Metab, Seoul 137701, South KoreaSungkyunkwan Univ, Sch Med, Dept Endocrinol & Metab, Seoul 135710, South Korea
Kang, Moo-Il
Park, Sung-Woo
论文数: 0引用数: 0
h-index: 0
机构:
Sungkyunkwan Univ, Sch Med, Dept Endocrinol & Metab, Seoul 135710, South KoreaSungkyunkwan Univ, Sch Med, Dept Endocrinol & Metab, Seoul 135710, South Korea
Park, Sung-Woo
Kim, Sun-Woo
论文数: 0引用数: 0
h-index: 0
机构:
Sungkyunkwan Univ, Sch Med, Dept Endocrinol & Metab, Seoul 135710, South KoreaSungkyunkwan Univ, Sch Med, Dept Endocrinol & Metab, Seoul 135710, South Korea
机构:
Dalian Med Univ, Affiliated Hosp 1, Dept Gastroenterol, Dalian, Peoples R ChinaDalian Med Univ, Affiliated Hosp 1, Dept Gastroenterol, Dalian, Peoples R China
Zhang, Zhi-Feng
Yang, Ning
论文数: 0引用数: 0
h-index: 0
机构:
Dalian Med Univ, Affiliated Hosp 1, Dept Nephrol, Dalian, Peoples R ChinaDalian Med Univ, Affiliated Hosp 1, Dept Gastroenterol, Dalian, Peoples R China
Yang, Ning
Zhao, Gang
论文数: 0引用数: 0
h-index: 0
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Dalian Med Univ, Affiliated Hosp 1, Dept Gastroenterol, Dalian, Peoples R ChinaDalian Med Univ, Affiliated Hosp 1, Dept Gastroenterol, Dalian, Peoples R China
Zhao, Gang
Zhu, Lei
论文数: 0引用数: 0
h-index: 0
机构:
Dalian Med Univ, Affiliated Hosp 1, Dept Gastroenterol, Dalian, Peoples R ChinaDalian Med Univ, Affiliated Hosp 1, Dept Gastroenterol, Dalian, Peoples R China
Zhu, Lei
Wang, Li-Xia
论文数: 0引用数: 0
h-index: 0
机构:
Dalian Med Univ, Affiliated Hosp 1, Dept Gastroenterol, Dalian, Peoples R ChinaDalian Med Univ, Affiliated Hosp 1, Dept Gastroenterol, Dalian, Peoples R China
机构:
Sun Yat Sen Univ, Dept Nephrol, Affiliated Hosp 6, Guangzhou 510655, Guangdong, Peoples R ChinaSun Yat Sen Univ, Dept Nephrol, Affiliated Hosp 6, Guangzhou 510655, Guangdong, Peoples R China
Zhou, Tian-Biao
Guo, Xue-Feng
论文数: 0引用数: 0
h-index: 0
机构:
Sun Yat Sen Univ, Dept Colorectal Surg, Affiliated Hosp 6, Guangzhou 510655, Guangdong, Peoples R ChinaSun Yat Sen Univ, Dept Nephrol, Affiliated Hosp 6, Guangzhou 510655, Guangdong, Peoples R China
Guo, Xue-Feng
Yin, Sheng-Sheng
论文数: 0引用数: 0
h-index: 0
机构:
Sun Yat Sen Univ, Dept Sci Grad, Affiliated Hosp 6, Guangzhou 510655, Guangdong, Peoples R ChinaSun Yat Sen Univ, Dept Nephrol, Affiliated Hosp 6, Guangzhou 510655, Guangdong, Peoples R China