Survival and complications after neoadjuvant chemotherapy or chemoradiotherapy for esophageal cancer: a meta-analysis

被引：47

作者：

Han, Jinmin ^{[2
,3
,4
]}

Wang, Zhongtang ^{[3
,4
]}

Liu, Chengxin ^{[1
,3
,4
,5
]}

机构：

[1] Shandong Univ, Cheeloo Coll Med, Jinan 250012, Peoples R China

[2] Shandong First Med Univ, Jinan 250117, Peoples R China

[3] Shandong Acad Med Sci, Jinan 250117, Peoples R China

[4] Shandong First Med Univ, Shandong Canc Hosp & Inst, Dept Radiat Oncol, Jinan 250117, Peoples R China

[5] Shandong Canc Hosp & Inst, Dept Radiat Oncol, Jinan 250117, Peoples R China

来源：

FUTURE ONCOLOGY | 2021年 / 17卷 / 17期

基金：

中国国家自然科学基金;

关键词：

complications; esophageal cancer; meta-analysis; neoadjuvant treatment; survival; PHASE-III TRIAL; PREOPERATIVE CHEMORADIOTHERAPY; PERIOPERATIVE CHEMOTHERAPY; RESECTABLE ESOPHAGEAL; CHEMORADIATION; THERAPY; ADENOCARCINOMA; CARCINOMA; SURGERY; RADIOCHEMOTHERAPY;

D O I：

10.2217/fon-2021-0021

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Objectives: To identify the effective approach between neoadjuvant chemotherapy (NCT) and chemoradiotherapy (NCRT) by comparing patient survival and complications. Methods: A systematic literature search of articles published between January 1980 and October 2020 was conducted. Data were extracted and analyzed with STATA 12.0. Results: Five randomized trials and 15 retrospective studies, including 4529 patients (NCT: 2035; NCRT: 2494), were enrolled. Compared with NCT, NCRT provided a higher 3-year survival benefit, higher R0 resection and pathological complete response rates and lower local recurrence and distant metastasis rates, but no increase in 5-year survival. Perioperative mortality and cardiovascular complications were more common in patients with adenocarcinoma. Conclusions: Further studies should concentrate on identifying the optimal neoadjuvant approach and suitable beneficiaries.

引用

页码：2257 / 2274

页数：18

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