Survival and complications after neoadjuvant chemotherapy or chemoradiotherapy for esophageal cancer: a meta-analysis

被引：47

作者：

Han, Jinmin ^{[2
,3
,4
]}

Wang, Zhongtang ^{[3
,4
]}

Liu, Chengxin ^{[1
,3
,4
,5
]}

机构：

[1] Shandong Univ, Cheeloo Coll Med, Jinan 250012, Peoples R China

[2] Shandong First Med Univ, Jinan 250117, Peoples R China

[3] Shandong Acad Med Sci, Jinan 250117, Peoples R China

[4] Shandong First Med Univ, Shandong Canc Hosp & Inst, Dept Radiat Oncol, Jinan 250117, Peoples R China

[5] Shandong Canc Hosp & Inst, Dept Radiat Oncol, Jinan 250117, Peoples R China

来源：

FUTURE ONCOLOGY | 2021年 / 17卷 / 17期

基金：

中国国家自然科学基金;

关键词：

complications; esophageal cancer; meta-analysis; neoadjuvant treatment; survival; PHASE-III TRIAL; PREOPERATIVE CHEMORADIOTHERAPY; PERIOPERATIVE CHEMOTHERAPY; RESECTABLE ESOPHAGEAL; CHEMORADIATION; THERAPY; ADENOCARCINOMA; CARCINOMA; SURGERY; RADIOCHEMOTHERAPY;

D O I：

10.2217/fon-2021-0021

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Objectives: To identify the effective approach between neoadjuvant chemotherapy (NCT) and chemoradiotherapy (NCRT) by comparing patient survival and complications. Methods: A systematic literature search of articles published between January 1980 and October 2020 was conducted. Data were extracted and analyzed with STATA 12.0. Results: Five randomized trials and 15 retrospective studies, including 4529 patients (NCT: 2035; NCRT: 2494), were enrolled. Compared with NCT, NCRT provided a higher 3-year survival benefit, higher R0 resection and pathological complete response rates and lower local recurrence and distant metastasis rates, but no increase in 5-year survival. Perioperative mortality and cardiovascular complications were more common in patients with adenocarcinoma. Conclusions: Further studies should concentrate on identifying the optimal neoadjuvant approach and suitable beneficiaries.

引用

页码：2257 / 2274

页数：18

共 46 条

[1] A prospective comparison of multidisciplinary treatment of oesophageal cancer with curative intent in a UK cancer network [J].

Adams, R. ;

Morgan, M. ;

Mukherjee, S. ;

Brewster, A. ;

Maughan, T. ;

Morrey, D. ;

Havard, T. ;

Lewis, W. ;

Clark, G. ;

Roberts, S. ;

Vachtsevanos, L. ;

Leong, J. ;

Hardwick, R. ;

Carey, D. ;

Crosby, T. .

EJSO, 2007, 33 (03) :307-313

[2]

Agha, 2018, STRAHLENTHER ONKOL, V1942

[3] Esophageal and Esophagogastric Junction Cancers, Version 2.2019 [J].

Ajani, Jaffer A. ;

D'Amico, Thomas A. ;

Bentrem, David J. ;

Chao, Joseph ;

Corvera, Carlos ;

Das, Prajnan ;

Denlinger, Crystal S. ;

Enzinger, Peter C. ;

Fanta, Paul ;

Farjah, Farhood ;

Gerdes, Hans ;

Gibson, Michael ;

Glasgow, Robert E. ;

Hayman, James A. ;

Hochwald, Steven ;

Hofstetter, Wayne L. ;

Ilson, David H. ;

Jaroszewski, Dawn ;

Johung, Kimberly L. ;

Keswani, Rajesh N. ;

Kleinberg, Lawrence R. ;

Leong, Stephen ;

Ly, Quan P. ;

Matkowskyj, Kristina A. ;

McNamara, Michael ;

Mulcahy, Mary F. ;

Paluri, Ravi K. ;

Park, Haeseong ;

Perry, Kyle A. ;

Pimiento, Jose ;

Poultsides, George A. ;

Roses, Robert ;

Strong, Vivian E. ;

Wiesner, Georgia ;

Willett, Christopher G. ;

Wright, Cameron D. ;

McMillian, Nicole R. ;

Pluchino, Lenora A. .

JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK, 2019, 17 (07) :855-883

[4] Preoperative Chemoradiotherapy Versus Perioperative Chemotherapy for Patients With Resectable Esophageal or Gastroesophageal Junction Adenocarcinoma [J].

Anderegg, M. C. J. ;

van der Sluis, P. C. ;

Ruurda, J. P. ;

Gisbertz, S. S. ;

Hulshof, M. C. C. M. ;

van Vulpen, M. ;

Mohammed, N. Haj ;

van Laarhoven, H. W. M. ;

Wiezer, M. J. ;

Los, M. ;

Henegouwen, M. I. van Berge ;

van Hillegersberg, R. .

ANNALS OF SURGICAL ONCOLOGY, 2017, 24 (08) :2282-2290

[5] A Randomized Trial Comparing Postoperative Adjuvant Chemotherapy with Cisplatin and 5-Fluorouracil Versus Preoperative Chemotherapy for Localized Advanced Squamous Cell Carcinoma of the Thoracic Esophagus (JCOG9907) [J].

Ando, Nobutoshi ;

Kato, Hoichi ;

Igaki, Hiroyasu ;

Shinoda, Masayuki ;

Ozawa, Soji ;

Shimizu, Hideaki ;

Nakamura, Tsutomu ;

Yabusaki, Hiroshi ;

Aoyama, Norio ;

Kurita, Akira ;

Ikeda, Kenichiro ;

Kanda, Tatsuo ;

Tsujinaka, Toshimasa ;

Nakamura, Kenichi ;

Fukuda, Haruhiko .

ANNALS OF SURGICAL ONCOLOGY, 2012, 19 (01) :68-74

[6]

Bancewicz J, 2002, LANCET, V359, P1727

[7] Responders benefit from neoadjuvant radiochemotherapy in esophageal squamous cell carcinoma:: results of a prospective phase-II trial [J].

Brücher, BLDM ;

Stein, HJ ;

Zimmermann, F ;

Werner, M ;

Sarbia, M ;

Busch, R ;

Dittler, HJ ;

Molls, M ;

Fink, U ;

Siewert, JR .

EJSO, 2004, 30 (09) :963-971

[8] Is concurrent radiation therapy required in patients receiving preoperative chemotherapy for adenocarcinoma of the oesophagus? A randomised phase II trial [J].

Burmeister, Bryan H. ;

Thomas, Janine M. ;

Burmeister, Elizabeth A. ;

Walpole, Euan T. ;

Harvey, Jennifer A. ;

Thomson, Damien B. ;

Barbour, Andrew P. ;

Gotley, David C. ;

Smithers, B. Mark .

EUROPEAN JOURNAL OF CANCER, 2011, 47 (03) :354-360

[9] Effects of neoadjuvant radiochemotherapy on pathological staging and prognosis for locally advanced esophageal squamous cell carcinoma [J].

Cao, X. -F. ;

He, X. -T. ;

Ji, L. ;

Xiao, J. ;

Lv, J. .

DISEASES OF THE ESOPHAGUS, 2009, 22 (06) :477-481

[10] Perioperative chemotherapy versus surgery alone for resectable gastroesophageal cancer [J].

Cunningham, David ;

Allum, William H. ;

Stenning, Sally P. ;

Thompson, Jeremy N. ;

Van de Velde, Cornelis J. H. ;

Nicolson, Marianne ;

Scarffe, J. Howard ;

Lofts, Fiona J. ;

Falk, Stephen J. ;

Iveson, Timothy J. ;

Smith, David B. ;

Langley, Ruth E. ;

Verma, Monica ;

Weeden, Simon ;

Chua, Yu Jo .

NEW ENGLAND JOURNAL OF MEDICINE, 2006, 355 (01) :11-20

← 1 2 3 4 5 →