Neuropsychiatric symptoms in patients with idiopathic normal pressure hydrocephalus

被引：0

作者：

Kito, Yumiko ^{[1
]}

Kazui, Hiroaki ^{[1
,2
]}

Kubo, Yoshihiko ^{[1
]}

Yoshida, Tetsuhiko ^{[1
,3
]}

Takaya, Masahiko ^{[1
]}

Wada, Tamiki ^{[1
]}

Nomura, Keiko ^{[1
]}

Hashimoto, Mamoru ^{[4
,5
]}

Ohkawa, Shingo ^{[4
,6
]}

Miyake, Hiroji ^{[7
]}

Ishikawa, Masatsune ^{[8
,9
]}

Takeda, Masatoshi ^{[1
]}

机构：

[1] Osaka Univ, Dept Integrated Med, Div Internal Med, Grad Sch Med, Suita, Osaka 5650871, Japan

[2] Kansai Rousai Hosp, Japan Labour Hlth & Welf Org, Dept Psychiat, Amagasaki, Hyogo, Japan

[3] Osaka Natl Hosp, Dept Psychiat, Natl Hosp Org, Chuo Ku, Osaka, Japan

[4] Hyogo Brain & Heart Ctr, Inst Aging Brain & Cognit Disorders, Himeji, Hyogo, Japan

[5] Kumamoto Univ, Dept Psychiat & Neuropathobiol, Grad Sch Med Sci, Kumamoto, Japan

[6] Ohue Hosp, Asagoshi, Hyogo, Japan

[7] Nishinomiya Kyoritsu Neurosurg Hosp, Nishinomiya, Hyogo, Japan

[8] Kitano Hosp, Dept Neurosurg, Kita Ku, Osaka, Japan

[9] Rakuwakai Otowa Hosp, Dept Neurosurg, Yamashina Ku, Kyoto, Japan

来源：

BEHAVIOURAL NEUROLOGY | 2009年 / 21卷 / 3-4期

关键词：

idiopathic normal pressure hydrocephalus; neuropsychiatric symptoms; apathy; Neuropsychiatric Inventory (NPI); Alzheimer's disease; CEREBRAL-BLOOD-FLOW; MILD COGNITIVE IMPAIRMENT; QUALITY-OF-LIFE; ALZHEIMERS-DISEASE; OCCULT HYDROCEPHALUS; RISK-FACTORS; AGGRESSION; DEMENTIA; APATHY; SPECT;

D O I：

10.1155/2009/791491

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Objective: To clarify the characteristics of neuropsychiatric symptoms in patients with idiopathic normal pressure hydrocephalus (iNPH). Methods: Neuropsychiatric symptoms of 64 iNPH patients with mild triad symptoms from three kinds of hospitals were evaluated with the Neuropsychiatric Inventory (NPI) and compared with 126 patients with Alzheimer's disease (AD). Results: The most frequently observed neuropsychiatric symptom in the iNPH patients was apathy followed by anxiety and aggression. No symptom was more prevalent or more severe in iNPH than in AD. The severity of cognitive impairment was correlated with both aberrant motor activity and apathy. Conclusions: Neuropsychiatric symptoms were mild in patients with iNPH and apathy was the most prevalent symptom. The cot-relation between neuropsychiatric symptoms and cognitive impairment in iNPH appears to arise from it common pathology in the frontal lobe.

引用

页码：165 / 174

页数：10

共 50 条

[31] Cerebrospinal fluid biomarkers that reflect clinical symptoms in idiopathic normal pressure hydrocephalus patients [J].

Lukkarinen, Heikki ;

Jeppsson, Anna ;

Wikkelso, Carsten ;

Blennow, Kaj ;

Zetterberg, Henrik ;

Constantinescu, Radu ;

Remes, Anne M. ;

Herukka, Sanna-Kaisa ;

Hiltunen, Mikko ;

Rauramaa, Tuomas ;

Nagga, Katarina ;

Leinonen, Ville ;

Tullberg, Mats .

FLUIDS AND BARRIERS OF THE CNS, 2022, 19 (01)

[32] Multimodal analysis to predict shunt surgery outcome of 284 patients with suspected idiopathic normal pressure hydrocephalus [J].

Luikku, Antti J. ;

Hall, Anette ;

Nerg, Ossi ;

Koivisto, Anne M. ;

Hiltunen, Mikko ;

Helisalmi, Seppo ;

Herukka, Sanna-Kaisa ;

Sutela, Anna ;

Kojoukhova, Maria ;

Mattila, Jussi ;

Lotjonen, Jyrki ;

Rummukainen, Jaana ;

Alafuzoff, Irina ;

Jaaskelainen, Juha E. ;

Remes, Anne M. ;

Soininen, Hilkka ;

Leinonen, Ville .

ACTA NEUROCHIRURGICA, 2016, 158 (12) :2311-2319

[33] The Expression of Transthyretin and Amyloid-β Protein Precursor is Altered in the Brain of Idiopathic Normal Pressure Hydrocephalus Patients [J].

Laitera, Tiina ;

Kurki, Mitja I. ;

Pursiheimo, Juha-Pekka ;

Zetterberg, Henrik ;

Helisalmi, Seppo ;

Rauramaa, Tuomas ;

Alafuzoff, Irina ;

Remes, Anne M. ;

Soininen, Hilkka ;

Haapasalo, Annakaisa ;

Jaaskelainen, Juha E. ;

Hiltunen, Mikko ;

Leinonen, Ville .

JOURNAL OF ALZHEIMERS DISEASE, 2015, 48 (04) :959-968

[34] Pathophysiological Mechanisms Underlying Idiopathic Normal Pressure Hydrocephalus: A Review of Recent Insights [J].

Bonney, Phillip A. ;

Briggs, Robert G. ;

Wu, Kevin ;

Choi, Wooseong ;

Khahera, Anadjeet ;

Ojogho, Brandon ;

Shao, Xingfeng ;

Zhao, Zhen ;

Borzage, Matthew ;

Wang, Danny J. J. ;

Liu, Charles ;

Lee, Darrin J. .

FRONTIERS IN AGING NEUROSCIENCE, 2022, 14

[35] Counting-backward test for executive function in idiopathic normal pressure hydrocephalus [J].

Kanno, S. ;

Saito, M. ;

Hayashi, A. ;

Uchiyama, M. ;

Hiraoka, K. ;

Nishio, Y. ;

Hisanaga, K. ;

Mori, E. .

ACTA NEUROLOGICA SCANDINAVICA, 2012, 126 (04) :279-286

[36] Cerebrospinal Fluid Amyloid-β Oligomer Levels in Patients with Idiopathic Normal Pressure Hydrocephalus [J].

Kawamura, Kaito ;

Miyajima, Masakazu ;

Nakajima, Madoka ;

Kanai, Mitsuyasu ;

Motoi, Yumiko ;

Nojiri, Shuko ;

Akiba, Chihiro ;

Ogino, Ikuko ;

Xu, Hanbing ;

Kamohara, Chihiro ;

Yamada, Shinya ;

Karagiozov, Kostadin ;

Ikeuchi, Takeshi ;

Kondo, Akihide ;

Arai, Hajime .

JOURNAL OF ALZHEIMERS DISEASE, 2021, 83 (01) :179-190

[37] Pathological mitochondria in neurons and perivascular astrocytic endfeet of idiopathic normal pressure hydrocephalus patients [J].

Hasan-Olive, Md Mahdi ;

Enger, Rune ;

Hansson, Hans-Arne ;

Nagelhus, Erlend A. ;

Eide, Per Kristian .

FLUIDS AND BARRIERS OF THE CNS, 2019, 16 (01)

[38] Association between cognitive impairment and gait disturbance in patients with idiopathic normal pressure hydrocephalus [J].

Miyoshi, N ;

Kazui, H ;

Ogino, A ;

Ishikawa, M ;

Miyake, H ;

Tokunaga, H ;

Ikejiri, Y ;

Takeda, M .

DEMENTIA AND GERIATRIC COGNITIVE DISORDERS, 2005, 20 (2-3) :71-76

[39] Associations of intracranial pressure with brain biopsy, radiological findings, and shunt surgery outcome in patients with suspected idiopathic normal pressure hydrocephalus [J].

Kojoukhova, Maria ;

Vanha, Krista-Irina ;

Timonen, Matti ;

Koivisto, Anne M. ;

Nerg, Ossi ;

Rummukainen, Jaana ;

Rauramaa, Tuomas ;

Vanninen, Ritva ;

Jaaskelainen, Juha E. ;

Sutela, Anna ;

Leinonen, Ville .

ACTA NEUROCHIRURGICA, 2017, 159 (01) :51-61

[40] Ongoing search for diagnostic biomarkers in idiopathic normal pressure hydrocephalus [J].

Tarnaris, Andrew ;

Toma, Ahmed K. ;

Kitchen, Neil D. ;

Watkins, Laurence D. .

BIOMARKERS IN MEDICINE, 2009, 3 (06) :787-805

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