Phosphorylation of Bruton's tyrosine kinase by c-Abl

被引：27

作者：

Bäckesjö, CM ^{[1
]}

Vargas, L

Superti-Furga, G

Smith, CIE

机构：

[1] Huddinge Univ Hosp, Karolinska Inst, Clin Res Ctr, SE-14186 Huddinge, Sweden

[2] European Mol Biol Lab, Dev Biol Programme, D-69117 Heidelberg, Germany

[3] Cellzome AG, D-69117 Heidelberg, Germany

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2002年 / 299卷 / 03期

关键词：

Bruton's tyrosine kinase; Btk; c-Abl; tyrosine phosphorylation; SH3;

D O I：

10.1016/S0006-291X(02)02643-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Bruton's tyrosine kinase (Btk) is necessary for B-lymphocyte development. Mutation in the gene coding for Btk causes X-linked agammaglobulinemia (XLA) in humans. Similar to Btk, c-Abl is a tyrosine kinase shuttling between the cytoplasm and the nucleus where it is involved in different functions depending on the localization. In this report we describe for the first time that c-AbI and Btk physically interact and that c-Abl can phosphorylate tyrosine 223 in the SH3 domain of Btk. Interestingly, the Btk sequence matched the preferred, known v-Abl substrate identified from a randomized peptide library and was also highly related to a number of previously found c-Abl substrates. (C) 2002 Elsevier Science (USA). All rights reserved.

引用

页码：510 / 515

页数：6

共 35 条

[1] Regulation of the oncogenic activity of BCR-ABL by a tightly bound substrate protein RIN1 [J].

Afar, DEH ;

Han, LM ;

McLaughlin, J ;

Wong, S ;

Dhaka, A ;

Parmar, K ;

Rosenberg, N ;

Witte, ON ;

Colicelli, J .

IMMUNITY, 1997, 6 (06) :773-782

[2]

Andoniou CE, 1996, ONCOGENE, V12, P1981

[3] An intramolecular SH3-domain interaction regulates c-Abl activity [J].

Barilá, D ;

Superti-Furga, G .

NATURE GENETICS, 1998, 18 (03) :280-282

[4] p62(dok): A constitutively tyrosine-phosphorylated, GAP-associated protein in chronic myelogenous leukemia progenitor cells [J].

Carpino, N ;

Wisniewski, D ;

Strife, A ;

Marshak, D ;

Kobayashi, R ;

Stillman, B ;

Clarkson, B .

CELL, 1997, 88 (02) :197-204

[5] Selection of v-abl tyrosine kinase substrate sequences from randomized peptide and cellular proteomic libraries using mRNA display [J].

Cujec, TP ;

Medeiros, PF ;

Hammond, P ;

Rise, C ;

Kreider, BL .

CHEMISTRY & BIOLOGY, 2002, 9 (02) :253-264

[6] c-Abl is an effector of Src for growth factor-induced c-myc expression and DNA synthesis [J].

Furstoss, O ;

Dorey, K ;

Simon, V ;

Barilà, D ;

Superti-Furga, G ;

Roche, S .

EMBO JOURNAL, 2002, 21 (04) :514-524

[7] The role of the linker between the SH2 domain and catalytic domain in the regulation and function of Src [J].

Gonfloni, S ;

Williams, JC ;

Hattula, K ;

Weijland, A ;

Wierenga, RK ;

Superti-Furga, G .

EMBO JOURNAL, 1997, 16 (24) :7261-7271

[8] Protein binding and signaling properties of RIN1 suggest a unique effector function [J].

Han, LM ;

Wong, D ;

Dhaka, A ;

Afar, D ;

White, M ;

Xie, WL ;

Herschman, H ;

Witte, O ;

Colicelli, J .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (10) :4954-4959

[9] Solution structure of the SH3 domain from Bruton's tyrosine kinase [J].

Hansson, H ;

Mattsson, PT ;

Allard, P ;

Haapaniemi, P ;

Vihinen, M ;

Smith, CIE ;

Härd, T .

BIOCHEMISTRY, 1998, 37 (09) :2912-2924

[10] Src family kinases are required for integrin but not PDGFR signal transduction [J].

Klinghoffer, RA ;

Sachsenmaier, C ;

Cooper, JA ;

Soriano, P .

EMBO JOURNAL, 1999, 18 (09) :2459-2471

← 1 2 3 4 →