Control of the circannual rhythm of reproduction by melatonin in the ewe

被引:82
作者
Malpaux, B [1 ]
Viguie, C [1 ]
Skinner, DC [1 ]
Thiery, JC [1 ]
Chemineau, P [1 ]
机构
[1] BABRAHAM INST, DEPT NEUROBIOL, CAMBRIDGE CB2 4AT, ENGLAND
关键词
sheep; reproduction; circannual; melatonin; dopamine; LHRH;
D O I
10.1016/S0361-9230(97)00223-2
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Annual variations in day length are responsible for seasonal changes in reproductive activity in sheep, However, in constant photoperiodic conditions, ewes express an endogenous rhythm characterized by alternations of reproductive activity and quiescence that are not synchronized among animals. Thus, the main role of photoperiod in the natural environment appears to be the synchronization of this endogenous rhythm, Photoperiodic information is processed through a complex nervous and endocrine pathway to modulate reproductive activity, Light information perceived at the level of the retina is transformed through neural processing into an endocrine signal by the pineal gland: the nocturnal increase in melatonin release, Recent studies strongly suggest that melatonin has a hypothalamic target to modulate the reproductive neuroendocrine axis, Most LHRH perikarya are located in the preoptic area, but this region is devoid of melatonin receptors, and microimplants of melatonin placed in the preoptic area do not effect LHRH release, Thus, melatonin influences LHRH neurones indirectly and must involve interneurons. Good evidence now exists to demonstrate that a population of dopaminergic neurons with axons projecting to the median eminence is one of these interneurons. (C) 1997 Elsevier Science Inc.
引用
收藏
页码:431 / 438
页数:8
相关论文
共 61 条
[1]  
BITTMAN EL, 1993, AM ZOOL, V33, P200
[2]   LHRH-IMMUNOREACTIVE STRUCTURES IN THE SHEEP BRAIN [J].
CALDANI, M ;
BATAILLER, M ;
THIERY, JC ;
DUBOIS, MP .
HISTOCHEMISTRY, 1988, 89 (02) :129-139
[3]  
CHABOT V, 1994, 22 COLL SOC NEUR EXP
[4]   SEASONAL PROLACTIN SECRETION AND ITS ROLE IN SEASONAL REPRODUCTION - A REVIEW [J].
CURLEWIS, JD .
REPRODUCTION FERTILITY AND DEVELOPMENT, 1992, 4 (01) :1-23
[5]   MELATONIN BINDING-SITES IN THE SHEEP PARS TUBERALIS [J].
DEREVIERS, MM ;
RAVAULT, JP ;
TILLET, Y ;
PELLETIER, J .
NEUROSCIENCE LETTERS, 1989, 100 (1-3) :89-93
[6]  
Ducker M J, 1973, J Reprod Fertil Suppl, V19, P143
[7]   ESTRADIOL INCREASES TYROSINE-HYDROXYLASE ACTIVITY OF THE A15 NUCLEUS DOPAMINERGIC-NEURONS DURING LONG DAYS IN THE EWE [J].
GAYRARD, V ;
MALPAUX, B ;
TILLET, Y ;
THIERY, JC .
BIOLOGY OF REPRODUCTION, 1994, 50 (05) :1168-1177
[9]   DOPAMINERGIC STRUCTURES IN THE OVINE HYPOTHALAMUS MEDIATING ESTRADIOL NEGATIVE FEEDBACK IN ANESTROUS EWES [J].
HAVERN, RL ;
WHISNANT, CS ;
GOODMAN, RL .
ENDOCRINOLOGY, 1994, 134 (04) :1905-1914
[10]   HYPOTHALAMIC SITES OF CATECHOLAMINE INHIBITION OF LUTEINIZING-HORMONE IN THE ANESTROUS EWE [J].
HAVERN, RL ;
WHISNANT, CS ;
GOODMAN, RL .
BIOLOGY OF REPRODUCTION, 1991, 44 (03) :476-482