Infectivity of Plasmodium falciparum sporozoites determines emerging parasitemia in infected volunteers

被引：33

作者：

McCall, Matthew B. B. ^{[1
,6
,7
]}

Wammes, Linda J. ^{[1
]}

Langenberg, Marijke C. C. ^{[2
]}

van Gemert, Geert-Jan ^{[3
]}

Walk, Jona ^{[3
]}

Hermsen, Cornelus C. ^{[3
]}

Graumans, Wouter ^{[3
]}

Koelewijn, Rob ^{[1
,2
]}

Franetich, Jean-Francois ^{[4
]}

Chishimba, Sandra ^{[1
]}

Gerdsen, Max ^{[3
]}

Lorthiois, Audrey ^{[4
]}

van de Vegte, Marga ^{[3
]}

Mazier, Dominique ^{[4
,5
]}

Bijker, Else M. ^{[3
]}

van Hellemond, Jaap J. ^{[1
]}

van Genderen, Perry J. J. ^{[2
]}

Sauerwein, Robert W. ^{[3
]}

机构：

[1] Erasmus MC, Dept Med Microbiol & Infect Dis, Rotterdam, Netherlands

[2] Harbour Hosp, Inst Trop Dis, Rotterdam, Netherlands

[3] Radboud Univ Nijmegen, Med Ctr, Dept Med Microbiol, Nijmegen, Netherlands

[4] UPMC Univ Paris 06, Sorbonne Univ, Ctr Immunol & Malad Infect CIMI Paris, CNRS,ERL 8255,INSERM,U1135, 91 Bd Hop, F-75013 Paris, France

[5] Grp Hosp La Pitie Salpetriere, AP HP, Serv Parasitol Mycol, F-75013 Paris, France

[6] Ctr Rech Med Lambarene, Lambarene, Gabon

[7] Univ Tubingen, Inst Trop Med, Tubingen, Germany

来源：

SCIENCE TRANSLATIONAL MEDICINE | 2017年 / 9卷 / 395期

关键词：

HUMAN MALARIA INFECTION; LIVER-STAGE DEVELOPMENT; DIRECT VENOUS INOCULATION; CHLOROQUINE PROPHYLAXIS; ANOPHELES-STEPHENSI; PROTECTION; IMMUNIZATION; MOSQUITOS; CHALLENGE; DIVERSITY;

D O I：

10.1126/scitranslmed.aag2490

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Malaria sporozoites must first undergo intrahepatic development before a pathogenic blood-stage infection is established. The success of infection depends on host and parasite factors. In healthy human volunteers undergoing controlled human malaria infection (CHMI), we directly compared three clinical Plasmodium falciparum isolates for their ability to infect primary human hepatocytes in vitro and to drive the production of blood-stage parasites in vivo. Our data show a correlation between the efficiency of strain-specific sporozoite invasion of human hepatocytes and the dynamics of patent parasitemia in study subjects, highlighting intrinsic differences in infectivity among P. falciparum isolates from distinct geographical locales. The observed heterogeneity in infectivity among strains underscores the value of assessing the protective efficacy of candidate malaria vaccines against heterologous strains in the CHMI model.

引用

页数：9

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