Methanol and methyl group conversion in acetogenic bacteria: biochemistry, physiology and application

被引:47
作者
Kremp, Florian [1 ]
Mueller, Volker [1 ]
机构
[1] Goethe Univ Frankfurt, Inst Mol Biosci, Dept Mol Microbiol & Bioenerget, Max von Laue Str 9, D-60438 Frankfurt, Germany
基金
欧洲研究理事会;
关键词
biocommodities; acetogen; methyltransferase; value-added chemicals; biofuel; biotechnology;
D O I
10.1093/femsre/fuaa040
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The production of bulk chemicals mostly depends on exhausting petroleum sources and leads to emission of greenhouse gases. Within the last decades the urgent need for alternative sources has increased and the development of bio-based processes received new attention. To avoid the competition between the use of sugars as food or fuel, other feedstocks with high availability and low cost are needed, which brought acetogenic bacteria into focus. This group of anaerobic organisms uses mixtures of CO2, CO and H-2 for the production of mostly acetate and ethanol. Also methanol, a cheap and abundant bulk chemical produced from methane, is a suitable substrate for acetogenic bacteria. In methylotrophic acetogens the methyl group is transferred to the Wood-Ljungdahl pathway, a pathway to reduce CO2 to acetate via a series of C-1-intermediates bound to tetrahydrofolic acid. Here we describe the biochemistry and bioenergetics of methanol conversion in the biotechnologically interesting group of anaerobic, acetogenic bacteria. Further, the bioenergetics of biochemical production from methanol is discussed.
引用
收藏
页数:22
相关论文
共 193 条
  • [1] CLOSTRIDIUM AUTOETHANOGENUM, SP-NOV, AN ANAEROBIC BACTERIUM THAT PRODUCES ETHANOL FROM CARBON-MONOXIDE
    ABRINI, J
    NAVEAU, H
    NYNS, EJ
    [J]. ARCHIVES OF MICROBIOLOGY, 1994, 161 (04) : 345 - 351
  • [2] Improved operating strategy for continuous fermentation of carbon monoxide to fuel-ethanol by clostridia
    Abubackar, Haris Nalakath
    Bengelsdorf, Frank R.
    Duerre, Peter
    Veiga, Maria C.
    Kennes, Christian
    [J]. APPLIED ENERGY, 2016, 169 : 210 - 217
  • [3] FEATURES OF A CLOSTRIDIUM, STRAIN CV-AA1, AN OBLIGATORY ANAEROBIC BACTERIUM PRODUCING ACETIC-ACID FROM METHANOL
    ADAMSE, AD
    VELZEBOER, CTM
    [J]. ANTONIE VAN LEEUWENHOEK JOURNAL OF MICROBIOLOGY, 1982, 48 (04): : 305 - 313
  • [4] Alkalibaculum bacchi gen. nov., sp. nov., a CO-oxidizing, ethanol-producing acetogen isolated from livestock-impacted soil
    Allen, Toby D.
    Caldwell, Matthew E.
    Lawson, Paul A.
    Huhnke, Raymond L.
    Tanner, Ralph S.
    [J]. INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY, 2010, 60 : 2483 - 2489
  • [5] CLOSTRIDIUM-FORMICOACETICUM NOV-SPEC - ISOLATION, DESCRIPTION AND DISTINCTION FROM C-ACETICUM AND C-THERMOACETICUM
    ANDREESEN, JR
    GOTTSCHALK, G
    SCHLEGEL, HG
    [J]. ARCHIV FUR MIKROBIOLOGIE, 1970, 72 (02): : 154 - +
  • [6] SELECTIVE ISOLATION OF ACETOBACTERIUM-WOODII ON METHOXYLATED AROMATIC-ACIDS AND DETERMINATION OF GROWTH YIELDS
    BACHE, R
    PFENNIG, N
    [J]. ARCHIVES OF MICROBIOLOGY, 1981, 130 (03) : 255 - 261
  • [7] Methanol utilization by a novel thermophilic homoacetogenic bacterium, Moorella mulderi sp nov., isolated from a bioreactor
    Balk, M
    Weijma, J
    Friedrich, MW
    Stams, AJM
    [J]. ARCHIVES OF MICROBIOLOGY, 2003, 179 (05) : 315 - 320
  • [8] Bandarian V, 2002, NAT STRUCT BIOL, V9, P53
  • [9] IMPORTANCE OF TETRAHYDROFOLATE AND ATP IN THE ANAEROBIC O-DEMETHYLATION REACTION FOR PHENYLMETHYLETHERS
    BERMAN, MH
    FRAZER, AC
    [J]. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 1992, 58 (03) : 925 - 931
  • [10] A novel route for ethanol oxidation in the acetogenic bacterium Acetobacterium woodii: the acetaldehyde/ethanol dehydrogenase pathway
    Bertsch, Johannes
    Siemund, Anna Lena
    Kremp, Florian
    Mueller, Volker
    [J]. ENVIRONMENTAL MICROBIOLOGY, 2016, 18 (09) : 2913 - 2922