The global cysteine peptidase landscape in parasites

被引：77

作者：

Atkinson, Holly J. ^{[2
]}

Babbitt, Patricia C. ^{[3
,4
]}

Sajid, Mohammed ^{[1
,5
]}

机构：

[1] Univ Calif San Francisco, UCSF Sandler Ctr Basic Res Parasit Dis, San Francisco, CA 94158 USA

[2] Univ Calif San Francisco, UCSF Grad Program Biol & Med Informat, San Francisco, CA 94158 USA

[3] Univ Calif San Francisco, UCSF Dept Bioengn & Therapeut Sci, San Francisco, CA 94158 USA

[4] Univ Calif San Francisco, Dept Pharmaceut Chem, San Francisco, CA 94158 USA

[5] Leiden Univ, Med Ctr, Dept Parasitol, Leiden Malaria Res Grp, NL-2333 ZA Leiden, Netherlands

来源：

TRENDS IN PARASITOLOGY | 2009年 / 25卷 / 12期

关键词：

LEISHMANIA-MAJOR METACASPASE; PROGRAMMED CELL-DEATH; TRYPANOSOMA-BRUCEI; PLASMODIUM-FALCIPARUM; AFRICAN TRYPANOSOMES; CATHEPSIN-B; PROTEASES; ENZYMES; UNIQUE; FAMILY;

D O I：

10.1016/j.pt.2009.09.006

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

The accumulation of sequenced genomes has expanded the already sizeable population of cysteine peptidases from parasites. Characterization of a few of these enzymes has ascribed key roles to peptidases in parasite life cycles and has also shed light on mechanisms of pathogenesis. Here we discuss recent observations on the physiological activities of cysteine peptidases of parasitic organisms, paired with a global view of all cysteine peptidases from the MEROPS database grouped by similarity. This snapshot of the landscape of parasite cysteine peptidases is complex and highly populated, suggesting that expansion of research beyond the few 'model' parasite peptidases is now timely.

引用

页码：573 / 581

页数：9

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