Associations among Dietary Omega-3 Polyunsaturated Fatty Acids, the Gut Microbiota, and Intestinal Immunity

被引：225

作者：

Fu, Yawei ^{[1
,2
]}

Wang, Yadong ^{[1
,2
]}

Gao, Hu ^{[2
]}

Li, DongHua ^{[1
]}

Jiang, RuiRui ^{[1
]}

Ge, Lingrui ^{[3
]}

Tong, Chao ^{[1
]}

Xu, Kang ^{[2
,4
]}

机构：

[1] Henan Agr Univ, Coll Anim Sci & Technol, Zhengzhou, Henan, Peoples R China

[2] Chinese Acad Sci, Inst Subtrop Agr, Key Lab Agroecol Proc Subtrop Reg, Changsha, Hunan, Peoples R China

[3] Hunan Biol & Electromech Polytech, Changsha, Hunan, Peoples R China

[4] Hunan Normal Univ, Coll Life Sci, State Key Lab Dev Biol Freshwater Fish, Changsha, Hunan, Peoples R China

来源：

MEDIATORS OF INFLAMMATION | 2021年 / 2021卷

基金：

中国国家自然科学基金;

关键词：

N-3 PUFAS DEFICIENCY; EICOSAPENTAENOIC ACID; HEALTH-BENEFITS; COLON-CANCER; FISH-OIL; OMEGA-3-FATTY-ACIDS; OBESITY; INFLAMMATION; MODULATION; ACTIVATION;

D O I：

10.1155/2021/8879227

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Omega-3 polyunsaturated fatty acids (omega-3 PUFAs), which are essential fatty acids that humans should obtain from diet, have potential benefits for human health. In addition to altering the structure and function of cell membranes, omega-3 PUFAs (docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), alpha-linolenic acid (ALA), and docosapentaenoic acid (DPA)) exert different effects on intestinal immune tolerance and gut microbiota maintenance. Firstly, we review the effect of omega-3 PUFAs on gut microbiota. And the effects of omega-3 PUFAs on intestinal immunity and inflammation were described. Furthermore, the important roles of omega-3 PUFAs in maintaining the balance between gut immunity and the gut microbiota were discussed. Additional factors, such as obesity and diseases (NAFLD, gastrointestinal malignancies or cancer, bacterial and viral infections), which are associated with variability in omega-3 PUFA metabolism, can influence omega-3 PUFAs-microbiome-immune system interactions in the intestinal tract and also play roles in regulating gut immunity. This review identifies several pathways by which the microbiota modulates the gut immune system through omega-3 PUFAs. Omega-3 supplementation can be targeted to specific pathways to prevent and alleviate intestinal diseases, which may help researchers identify innovative diagnostic methods.

引用

页数：11

共 105 条

[41] Human fetal colon cells and colon cancer cells respond differently to butyrate and PUFAs [J].

Hofmanova, Jirina ;

Vaculova, Alena ;

Koubkova, Zuzana ;

Hyzd'alova, Martina ;

Kozubik, Alois .

MOLECULAR NUTRITION & FOOD RESEARCH, 2009, 53 :S102-S113

[42] Association between blood omega-3 polyunsaturated fatty acids and the gut microbiota among breast cancer survivors [J].

Horigome, A. ;

Okubo, R. ;

Hamazaki, K. ;

Kinoshita, T. ;

Katsumata, N. ;

Uezono, Y. ;

Xiao, J. Z. ;

Matsuoka, Y. J. .

BENEFICIAL MICROBES, 2019, 10 (07) :751-758

[43] Reduction of n-3 PUFAs, specifically DHA and EPA, and enhancement of peroxisomal beta-oxidation in type 2 diabetic rat heart [J].

Hou, Lianguo ;

Lian, Kaoqi ;

Yao, Min ;

Shi, Yun ;

Lu, Xin ;

Fang, Lijia ;

He, Tianbo ;

Jiang, Lingling .

CARDIOVASCULAR DIABETOLOGY, 2012, 11

[44] Modulation of host defence against bacterial and viral infections by omega-3 polyunsaturated fatty acids [J].

Husson, Marie-Odile ;

Ley, Delphine ;

Portal, Celine ;

Gottrand, Madeleine ;

Hueso, Thomas ;

Desseyn, Jean-Luc ;

Gottrand, Frederic .

JOURNAL OF INFECTION, 2016, 73 (06) :523-535

[45] The Potential Effects of Probiotics and ω-3 Fatty Acids on Chronic Low-Grade Inflammation [J].

Hutchinson, Ashley N. ;

Tingo, Lina ;

Brummer, Robert Jan .

NUTRIENTS, 2020, 12 (08) :1-15

[46] Dietary n-6 PUFA deprivation for 15 weeks reduces arachidonic acid concentrations while increasing n-3 PUFA concentrations in organs of post-weaning male rats [J].

Igarashi, Miki ;

Gao, Fei ;

Kim, Hyung-Wook ;

Ma, Kaizong ;

Bell, Jane M. ;

Rapoport, Stanley I. .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 2009, 1791 (02) :132-139

[47] Functions of omega-3 fatty acids and FFA4 (GPR120) in macrophages [J].

Im, Dong-Soon .

EUROPEAN JOURNAL OF PHARMACOLOGY, 2016, 785 :36-43

[48] National Lipid Association Recommendations for Patient-Centered Management of Dyslipidemia: Part 1-Full Report [J].

Jacobson, Terry A. ;

Ito, Matthew K. ;

Maki, Kevin C. ;

Orringer, Carl E. ;

Bays, Harold E. ;

Jones, Peter H. ;

McKenney, James M. ;

Grundy, Scott M. ;

Gill, Edward A. ;

Wild, Robert A. ;

Wilson, Don P. ;

Brown, W. Virgil .

JOURNAL OF CLINICAL LIPIDOLOGY, 2015, 9 (02) :129-169

[49] Reduced colitis-associated colon cancer in fat-1 (n-3 fatty acid desaturase) transgenic mice [J].

Jia, Qian ;

Lupton, Joanne R. ;

Smith, Roger ;

Weeks, Brad R. ;

Callaway, Evelyn ;

Davidson, Laurie A. ;

Kim, Wooki ;

Fan, Yang-Yi ;

Yang, Peiying ;

Newman, Robert A. ;

Kang, Jing X. ;

McMurray, David N. ;

Chapkin, Robert S. .

CANCER RESEARCH, 2008, 68 (10) :3985-3991

[50] Omega-3 Polyunsaturated Fatty Acids and Cancer [J].

Jing, Kaipeng ;

Wu, Tong ;

Lim, Kyu .

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, 2013, 13 (08) :1162-1177

← 1 2 3 4 5 6 7 8 9 10 →