Associations among Dietary Omega-3 Polyunsaturated Fatty Acids, the Gut Microbiota, and Intestinal Immunity

被引：225
作者：
Fu, Yawei [1 ,2 ]
Wang, Yadong [1 ,2 ]
Gao, Hu [2 ]
Li, DongHua [1 ]
Jiang, RuiRui [1 ]
Ge, Lingrui [3 ]
Tong, Chao [1 ]
Xu, Kang [2 ,4 ]
机构：
[1] Henan Agr Univ, Coll Anim Sci & Technol, Zhengzhou, Henan, Peoples R China
[2] Chinese Acad Sci, Inst Subtrop Agr, Key Lab Agroecol Proc Subtrop Reg, Changsha, Hunan, Peoples R China
[3] Hunan Biol & Electromech Polytech, Changsha, Hunan, Peoples R China
[4] Hunan Normal Univ, Coll Life Sci, State Key Lab Dev Biol Freshwater Fish, Changsha, Hunan, Peoples R China
来源：
MEDIATORS OF INFLAMMATION | 2021年 / 2021卷
基金：
中国国家自然科学基金;
关键词：
N-3 PUFAS DEFICIENCY; EICOSAPENTAENOIC ACID; HEALTH-BENEFITS; COLON-CANCER; FISH-OIL; OMEGA-3-FATTY-ACIDS; OBESITY; INFLAMMATION; MODULATION; ACTIVATION;
D O I：
10.1155/2021/8879227
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Omega-3 polyunsaturated fatty acids (omega-3 PUFAs), which are essential fatty acids that humans should obtain from diet, have potential benefits for human health. In addition to altering the structure and function of cell membranes, omega-3 PUFAs (docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), alpha-linolenic acid (ALA), and docosapentaenoic acid (DPA)) exert different effects on intestinal immune tolerance and gut microbiota maintenance. Firstly, we review the effect of omega-3 PUFAs on gut microbiota. And the effects of omega-3 PUFAs on intestinal immunity and inflammation were described. Furthermore, the important roles of omega-3 PUFAs in maintaining the balance between gut immunity and the gut microbiota were discussed. Additional factors, such as obesity and diseases (NAFLD, gastrointestinal malignancies or cancer, bacterial and viral infections), which are associated with variability in omega-3 PUFA metabolism, can influence omega-3 PUFAs-microbiome-immune system interactions in the intestinal tract and also play roles in regulating gut immunity. This review identifies several pathways by which the microbiota modulates the gut immune system through omega-3 PUFAs. Omega-3 supplementation can be targeted to specific pathways to prevent and alleviate intestinal diseases, which may help researchers identify innovative diagnostic methods.
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页数：11
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