Biological and antibacterial properties of the micro-nanostructured hydroxyapatite/chitosan coating on titanium

被引:78
|
作者
Li, Baoe [1 ]
Xia, Xiaomei [1 ]
Guo, Miaoqi [1 ]
Jiang, Yu [1 ]
Li, Yu [1 ]
Zhang, Zhiyuan [1 ]
Liu, Shimin [2 ]
Li, Haipeng [1 ]
Liang, Chunyong [1 ]
Wang, Hongshui [1 ]
机构
[1] Hebei Univ Technol, Sch Mat Sci & Engn, Tianjin 300130, Peoples R China
[2] Tianjin Univ Commerce, Dept Gem & Mat Technol, Tianjin 300134, Peoples R China
基金
中国国家自然科学基金;
关键词
FORMATION MECHANISM; CHITOSAN; SURFACE;
D O I
10.1038/s41598-019-49941-0
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Titanium (Ti) is the widely used implant material in clinic, however, failures still frequently occur due to its bioinertness and poor antibacterial property. To improve the biological and antibacterial properties of Ti implants, micro-nanostructured hydroxyapatite (HA) coating was prepared on Ti surface by micro-arc oxidation (MAO), and then the antibacterial agent of chitosan (CS) was loaded on the HA surface through dip-coating method. The results showed that the obtained HA/CS composite coating accelerated the formation of apatite layer in SBF solution, enhanced cell adhesion, spreading and proliferation, and it also inhibited the bacterial growth, showing improved biological and antibacterial properties. Although, with the increased CS amount, the coverage of HA coating would be enlarged, resulting in depressed biological property, however, the antibacterial property of the composite coating was enhanced, and the cytotoxicity about CS was not detected in this work. In conclusion, the HA/CS coating has promising application in orthopedics, dentistry and other biomedical devices.
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页数:10
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