Host-dependent patterns of tissue injury in invasive pulmonary aspergillosis

被引:96
作者
Stergiopoulou, Theodouli
Meletiadis, Joseph
Roilides, Emmanuel
Kleiner, David E.
Schaufele, R.
Roden, Maureen
Harrington, Susan
Dad, Luqman
Segal, Brahm
Walsh, Thomas J.
机构
[1] NCI, CRC, POB, Immunocompromised Host Sect, Bethesda, MD 20892 USA
[2] NCI, Lab Pathol Dept, Bethesda, MD 20892 USA
[3] NIH, Ctr Clin, Dept Lab Med, Bethesda, MD 20892 USA
[4] Aristotle Univ Thessaloniki, Hippokrat Hosp, Pediat Dept 3, GR-54006 Thessaloniki, Greece
[5] Roswell Pk Canc Inst, Dept Med, Buffalo, NY 14263 USA
关键词
invasive pulmonary aspergillosis; neutropenia; hematopoietic stem cell transplant recipients; angioinvasion; corticosteroids; pulmonary infarct;
D O I
10.1309/UJRV9DLC11RM3G8R
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Invasive pulmonary aspergillosis (IPA) is an important cause of morbidity and mortality in neutropenic, nonneutropenic, and other immunocompromised patients. We therefore compared the patterns of infection and inflammation among 3 cohorts of immunocompromised patients with profound neutropenia, nonneutropenic immunosuppression, and hematopoietic stem cell transplantation. Lesions of IPA in neutropenic patients and hematopoietic stem cell transplant (HSCT) recipients were similar and consisted predominantly of angioinvasion and intraalveolar hemorrhage. The frequency of these histologic findings in neutropenic patients and HSCT recipients differed significantly from those of nonneutropenic patients (P < .05). It is noteworthy that even if HSCT recipients have normal peripheral blood neutrophil counts, there may be no influx into sites of infection. In the nonneutropenic cohort, lesions of IPA consisted mainly of neutrophilic and monocytic infiltrates and inflammatory necrosis. Thus, the status of innate host defenses contributes significantly to the histologic patterns observed in IPA.
引用
收藏
页码:349 / 355
页数:7
相关论文
共 50 条
[31]   Invasive pulmonary aspergillosis in patients with chronic obstructive pulmonary disease [J].
Barberan, Jose ;
Mensa, Jose .
REVISTA IBEROAMERICANA DE MICOLOGIA, 2014, 31 (04) :237-241
[32]   Clinical patterns among invasive pulmonary aspergillosis patients with and without recent intensive immunosuppressive therapy [J].
Chang, GC ;
Chang, KM ;
Wu, CL ;
Chiang, CD .
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION, 2001, 100 (11) :762-766
[33]   Invasive pulmonary aspergillosis: effects of early resection in a neutropenic rat model [J].
Habicht, JM ;
Preiss, M ;
Passweg, J ;
Dalquen, P ;
Matt, P ;
Adler, H ;
Frei, R ;
Zerkowski, HR .
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY, 2002, 22 (05) :728-732
[34]   A rare case of invasive pulmonary aspergillosis presenting as organizing pneumonia due to Aspergillus niger in an immunocompetent host [J].
Schils, Raphael ;
Altdorfer, Antoine ;
Moerman, Filip ;
Weber, Thierry ;
De Waele, Michele ;
Maertens, Johan ;
Pirotte, Benoit F. .
RESPIRATORY MEDICINE CASE REPORTS, 2021, 34
[35]   The value of surgery in the treatment of invasive pulmonary aspergillosis in neutropenic patients. [J].
Bernard, A ;
Caillot, D ;
Casasnovas, O ;
Couaillier, JF ;
Guy, H ;
Favre, JP .
REVUE DES MALADIES RESPIRATOIRES, 1998, 15 (01) :49-55
[36]   Immune reconstitution inflammatory syndrome in neutropenic patients with invasive pulmonary aspergillosis [J].
Jung, Jiwon ;
Hong, Hyo-Lim ;
Lee, Sang-Oh ;
Choi, Sang-Ho ;
Kim, Yang Soo ;
Woo, Jun Hee ;
Kim, Sung-Han .
JOURNAL OF INFECTION, 2015, 70 (06) :659-667
[37]   Discrimination between invasive pulmonary aspergillosis and pulmonary lymphoma using CT [J].
Kawel, Nadine ;
Schorer, Georg M. ;
Desbiolles, Lotus ;
Seifert, Burkhardt ;
Marincek, Borut ;
Boehm, Thomas .
EUROPEAN JOURNAL OF RADIOLOGY, 2011, 77 (03) :417-425
[38]   A rare case of invasive pulmonary aspergillosis in an immunocompetent individual [J].
Barroso, Andreia S. ;
Antunes, Mariana D. ;
Ribeiro, Analisa L. ;
Rodrigues, Cristina I. .
MINERVA RESPIRATORY MEDICINE, 2023, 62 (02) :95-100
[39]   Invasive pulmonary aspergillosis accompanied by soft tissue lesions during treatment of a patient with hyperthyroidism: a case report [J].
Fan, Xiao-Yun ;
Wang, Wei-Min ;
Yan, Xue-Bo ;
Wang, Cong-Hui ;
Liu, Rong-Yu .
CENTRAL EUROPEAN JOURNAL OF IMMUNOLOGY, 2015, 40 (01) :117-121
[40]   Autoinduction of Voriconazole Metabolism in a Child with Invasive Pulmonary Aspergillosis [J].
Hsu, Alice Jenh ;
Dabb, Alix ;
Arav-Boger, Ravit .
PHARMACOTHERAPY, 2015, 35 (04) :E20-E26