Widespread elevated expression of the human papilloma virus (HPV)-activating cellular transcription factor Brn-3a in the cervix of women with CIN3 (cervical intraepithelial neoplasia stage 3)

被引:11
作者
Ndisang, D
Budhram-Mahadeo, V
Singer, A
Latchman, DS
机构
[1] Inst Child Hlth, London WC1N 1EH, England
[2] Whittington Hosp, Dept Womens & Childrens Hlth, London N19 5NF, England
关键词
Brn-3a; cervical cancer; human papilloma virus; transforming proteins;
D O I
10.1042/CS19990350
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
引用
收藏
页码:601 / 602
页数:2
相关论文
共 6 条
[1]  
COX MF, 1986, LANCET, V2, P157
[2]   A PAPILLOMAVIRUS DNA FROM A CERVICAL-CARCINOMA AND ITS PREVALENCE IN CANCER BIOPSY SAMPLES FROM DIFFERENT GEOGRAPHIC REGIONS [J].
DURST, M ;
GISSMANN, L ;
IKENBERG, H ;
ZURHAUSEN, H .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (12) :3812-3815
[3]   THE OPPOSITE AND ANTAGONISTIC EFFECTS OF THE CLOSELY-RELATED POU FAMILY TRANSCRIPTION FACTORS BRN-3A AND BRN-3B ON THE ACTIVITY OF A TARGET PROMOTER ARE DEPENDENT ON DIFFERENCES IN THE POU DOMAIN [J].
MORRIS, PJ ;
THEIL, T ;
RING, CJA ;
LILLYCROP, KA ;
MOROY, T ;
LATCHMAN, DS .
MOLECULAR AND CELLULAR BIOLOGY, 1994, 14 (10) :6907-6914
[4]   The Brn-3a transcription factor plays a critical role in regulating human papilloma virus gene expression and determining the growth characteristics of cervical cancer cells [J].
Ndisang, D ;
Budhram-Mahadeo, V ;
Latchman, DS .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (40) :28521-28527
[5]   The HPV-activating cellular transcription factor Brn-3a is overexpressed in CIN3 cervical lesions [J].
Ndisdang, D ;
Morris, PJ ;
Chapman, C ;
Ho, L ;
Singer, A ;
Latchman, DS .
JOURNAL OF CLINICAL INVESTIGATION, 1998, 101 (08) :1687-1692
[6]   Role of a p53 polymorphism in the development of human papillomavirus-associated cancer [J].
Storey, A ;
Thomas, M ;
Kalita, A ;
Harwood, C ;
Gardiol, D ;
Mantovani, F ;
Breuer, J ;
Leigh, IM ;
Matlashewski, G ;
Banks, L .
NATURE, 1998, 393 (6682) :229-234