DNA binding studies of ruthenium(II) complexes containing asymmetric tridentate ligands

被引：231

作者：

Chao, H ^{[1
]}

Mei, WJ

Huang, QW

Ji, LN

机构：

[1] Zhongshan Univ, Dept Chem, Guangzhou 510275, Peoples R China

[2] Zhongshan Univ, State Key Lab Optoelect Mat & Technol, Guangzhou 510275, Peoples R China

[3] Shanghai Inst Organ Chem, State Key Lab Bioorgan & Nat Prod Chem, Shanghai 200032, Peoples R China

[4] Nanjing Univ, State Key Lab Coordinat Chem, Nanjing 210093, Peoples R China

来源：

JOURNAL OF INORGANIC BIOCHEMISTRY | 2002年 / 92卷 / 3-4期

基金：

中国国家自然科学基金; 美国国家科学基金会;

关键词：

ruthenium complexes; polypyridine ligands; DNA binding;

D O I：

10.1016/S0162-0134(02)00543-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Absorption spectroscopy, fluorescence spectroscopy and viscosity measurements have been used to characterize the DNA binding of [Ru(tpy)(dppt)](2+) (tpy=2,2':6',2"-terpyridine, dppt=3-(1,10-phenanthrolin-2-yl)-5,6-diphenyl-as-triazine), [Ru(tpy)(pta)](2+) (pta=3(1,10-phenanthrolin-2-yl)-as-triazino[5,6-f]acenaphthylene) and [Ru(tpy)(Ptp)](2+) (ptp=3-(1,10-phenanthrolin-2-yl)-as-triazino[5,6-f]phenanthrene). The results indicate that [Ru(tpy)(pta)](2+) and [Ru(tpy)(ptp)](2+) bindwith CT-DNA in an intercalative mode, while [Ru(tpy)(dppt)](2+) binds with DNA by partial intercalation. The ligand planarity of the complex has a significant effect on DNA binding affinity increases in the order [Ru(tpy)(dppt)](2+) <[Ru(tpy)(pta)](2+) <[Ru( tpy)(Ptp)](2+). (C) 2002 Elsevier Science Inc. All rights reserved.

引用

页码：165 / 170

页数：6

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