Stem cell therapy for the infarcted heart ("cellular cardiomyoplasty")

被引：22

作者：

Dengler, TJ ^{[1
]}

Katus, HA ^{[1
]}

机构：

[1] Heidelberg Univ, Internal Med Clin 3, Dept Cardiol Angiol & Pneumol, D-69115 Heidelberg, Germany

来源：

HERZ | 2002年 / 27卷 / 07期

关键词：

myocardial infarction; stem cell; cell transplantation; cellular cardiomyoplasty;

D O I：

10.1007/s00059-002-2412-5

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Myocardial infarction is the leading cause of heart failure in developed countries, because even the advanced therapeutic measures of today are usually not sufficient to prevent left ventricular remodeling as they fall short of actual replacement of necrotic cardiac myocytes. Recent new insights into stem cell biology have changed our understanding of regenerative activities in the infarcted heart and have raised considerable hopes for novel therapeutic approaches aimed at cardiac myocyte replacement/regeneration through cell transplantation ("cellular cardiomyoplasty"). Cell-Based Therapeutic Concepts: This review summarizes our present understanding of physiological stem cell/precursor cell mobilization to the infarcted heart and discusses the main therapeutic concepts for cell-based regeneration of myocardial infarction (adult/embryonic stem cells, skeletal myoblasts, endothelial precursors and others), including a brief over view of ongoing clinical trials. Finally, a short list of central clinical and research goals is provided, which should be addressed by stringently designed patient trials.

引用

页码：598 / 610

页数：13

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