Cellular and Molecular Differences Between Area CA1 and the Dentate Gyrus of the Hippocampus

被引：85

作者：

Alkadhi, Karim A. ^{[1
]}

机构：

[1] Univ Houston, Coll Pharm, Dept Pharmacol & Pharmaceut Sci, Houston, TX 77030 USA

来源：

MOLECULAR NEUROBIOLOGY | 2019年 / 56卷 / 09期

关键词：

Calbindin; Granule cell; Pyramidal cell; Ischemia; Chronic stress; Alzheimer' disease; Hypothyroidism; Obesity; OZR; Signaling molecules; Functional plasticity; Structural plasticity; LONG-TERM POTENTIATION; CHRONIC PSYCHOSOCIAL STRESS; HYPOTHYROIDISM-INDUCED IMPAIRMENT; DELAYED NEURONAL DEATH; CHRONIC LEAD-EXPOSURE; Y RECEPTOR SUBTYPES; SYNAPTIC PLASTICITY; RAT HIPPOCAMPUS; PYRAMIDAL CELLS; GRANULE CELLS;

D O I：

10.1007/s12035-019-1541-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

A distinct feature of the hippocampus of the brain is its unidirectional tri-synaptic pathway originating from the entorhinal cortex and projecting to the dentate gyrus (DG) then to area CA3 and subsequently, area CA1 of the Ammon's horn. Each of these areas of the hippocampus has its own cellular structure and distinctive function. The principal neurons in these areas are granule cells in the DG and pyramidal cells in the Ammon's horn's CA1 and CA3 areas with a vast network of interneurons. This review discusses the fundamental differences between the CA1 and DG areas regarding cell morphology, synaptic plasticity, signaling molecules, ability for neurogenesis, vulnerability to various insults and pathologies, and response to pharmacological agents.

引用

页码：6566 / 6580

页数：15

共 165 条

[1] Ontogeny of calbindin immunoreactivity in the human hippocampal formation with a special emphasis on granule cells of the dentate gyrus [J].

Abraham, Hajnalka ;

Veszpremi, Bela ;

Kravjak, Andras ;

Kovacs, Krisztina ;

Gomori, Eva ;

Seress, Laszlo .

INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE, 2009, 27 (02) :115-127

[2] Low-frequency stimulation does not readily cause long-term depression or depotentiation in the dentate gyrus of awake rats [J].

Abraham, WC ;

MasonParker, SE ;

Logan, B .

BRAIN RESEARCH, 1996, 722 (1-2) :217-221

[3] RECEPTOR-SELECTIVE ANALOGS DEMONSTRATE NPY PYY RECEPTOR HETEROGENEITY IN RAT-BRAIN [J].

AICHER, SA ;

SPRINGSTON, M ;

BERGER, SB ;

REIS, DJ ;

WAHLESTEDT, C .

NEUROSCIENCE LETTERS, 1991, 130 (01) :32-36

[4] SELECTIVE NEURONAL VULNERABILITY TO HYPOXIA INVITRO [J].

AITKEN, PG ;

SCHIFF, SJ .

NEUROSCIENCE LETTERS, 1986, 67 (01) :92-96

[5]

Akirav I, 1999, J NEUROSCI, V19, P10530

[6] Acute Nicotine Treatment Prevents REM Sleep Deprivation-Induced Learning and Memory Impairment in Rat [J].

Aleisa, A. M. ;

Helal, G. ;

Alhaider, I. A. ;

Alzoubi, K. H. ;

Srivareerat, M. ;

Tran, T. T. ;

Al-Rejaie, S. S. ;

Alkadhi, K. A. .

HIPPOCAMPUS, 2011, 21 (08) :899-909

[7] Post-learning REM sleep deprivation impairs long-term memory: Reversal by acute nicotine treatment [J].

Aleisa, A. M. ;

Alzoubi, K. H. ;

Alkadhi, K. A. .

NEUROSCIENCE LETTERS, 2011, 499 (01) :28-31

[8] Nicotine blocks stress-induced impairment of spatial memory and long-term potentiation of the hippocampal CA1 region [J].

Aleisa, Abdulaziz M. ;

Alzoubi, Karem H. ;

Gerges, Nashaat Z. ;

Alkadhi, Karim A. .

INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 2006, 9 (04) :417-426

[9] Chronic Caffeine Treatment Prevents Sleep Deprivation-Induced Impairment of Cognitive Function and Synaptic Plasticity [J].

Alhaider, Ibrahim A. ;

Aleisa, Abdulaziz M. ;

Tran, Trinh T. ;

Alzoubi, Karem H. ;

Alkadhi, Karim A. .

SLEEP, 2010, 33 (04) :437-444

[10] Chronic psychosocial stress impairs early LTP but not late LTP in the dentate gyrus of at-risk rat model of Alzheimer's disease [J].

Alkadhi, Karim A. ;

Tran, Trinh T. .

BRAIN RESEARCH, 2014, 1588 :150-158

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