Cerebellar outputs contribute to spontaneous and movement-related activity in the motor cortex of monkeys

被引：2

作者：

Sano, Nobuya ^{[1
,2
,3
,4
]}

Nakayama, Yoshihisa ^{[1
,2
]}

Ishida, Hiroaki ^{[1
,2
]}

Chiken, Satomi ^{[5
,6
]}

Hoshi, Eiji ^{[1
]}

Nambu, Atsushi ^{[5
,6
]}

Nishimura, Yukio ^{[2
,3
]}

机构：

[1] Tokyo Metropolitan Inst Med Sci, Dept Dementia & Higher Brain Funct, Frontal Lobe Funct Project, 2-1-6 Kamikitazawa, Tokyo, Tokyo 1568506, Japan

[2] Tokyo Metropolitan Inst Med Sci, Dept Dementia & Higher Brain Funct, Neural Prosthet Project, 2-1-6 Kamikitazawa, Tokyo, Tokyo 1568506, Japan

[3] Niigata Univ, Grad Sch Med & Dent Sci, Niigata 9518510, Japan

[4] Japan Soc Promot Sci, Chiyoda Ku, Tokyo 1020083, Japan

[5] Natl Inst Physiol Sci, Div Syst Neurophysiol, 38 Nishigonaka, Okazaki, Aichi 4448585, Japan

[6] SOKENDAI Grad Univ Adv Studies, Sch Life Sci, Dept Physiol Sci, Okazaki, Aichi 4448585, Japan

来源：

NEUROSCIENCE RESEARCH | 2021年 / 164卷

关键词：

Motor cortex; Cerebellum; Dentate nucleus; Motor control; Macaques; Muscimol inactivation;

D O I：

10.1016/j.neures.2020.03.010

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Cerebellar outputs originate from the dentate nucleus (DN), project to the primary motor cortex (M1) via the motor thalamus, control M1 activity, and play an essential role in coordinated movements. However, it is unclear when and how the cerebellar outputs contribute to M1 activity. To address this question, we examined the response of M1 neurons to electrical stimulation of the DN and M1 activity during performance of arm-reaching tasks. Based on response patterns to DN stimulation, M1 neurons were classified into facilitation-, suppression-, and no-response-types. During tasks, not only facilitation- and suppression-type M1 neurons, but also no response-type M1 neurons increased or decreased their firing rates in relation to arm reaching movements. However, the firing rates of facilitation- and suppression-type neurons were higher than those of no-response-type neurons during both inter-trial intervals and arm reaching movements. These results imply that cerebellar outputs contribute to both spontaneous and movement-related activity in the M1, which help to maintain muscle tones and execute coordinated movements, although other inputs also contribute to movement-related activity. Pharmacological inactivation of the DN supports this notion, in that DN inactivation reduced both spontaneous firing rates and movement-related activity in the M1. (C) 2020 Elsevier B.V. and Japan Neuroscience Society. All rights reserved.

引用

页码：10 / 21

页数：12

共 55 条

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