Quantitative Spot-Test Analysis of Metformin in Pharmaceutical Preparations Using Ultraviolet-Visible Diffuse Reflectance Spectroscopy

被引：5

作者：

Tubino, Matthieu ^{[1
]}

Bianchessi, Luis Francisco ^{[1
]}

Vila, Marta M. D. C. ^{[2
]}

机构：

[1] Univ Estadual Campinas, Inst Chem, BR-13083970 Campinas, SP, Brazil

[2] Univ Sorocaba, Sorocaba, SP, Brazil

来源：

ANALYTICAL SCIENCES | 2010年 / 26卷 / 01期

基金：

巴西圣保罗研究基金会;

关键词：

PHASE LIQUID-CHROMATOGRAPHY; MULTICOMPONENT DOSAGE FORMS; REFLECTOMETRIC METHOD; PURE FORM; FORMULATIONS; HYDROCHLORIDE; SPECTROPHOTOMETRY; ROSIGLITAZONE; SPECTROMETRY; GLIPIZIDE;

D O I：

10.2116/analsci.26.121

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A quantitative spot-test for the determination of metformin in pharmaceutical preparations using diffuse UV-visible reflectance is reported. The procedure is quite simple, involving in the formation of a metformin-nickel(II) complex on a glass filter membrane with a later measurement of the reflectance in the spectrophotometer using an integration sphere. The analytical results obtained with commercial products were statistically compared with those resulting from a method recommended by JP and by USP, where complete agreement was observed. The average RSD is 2.5% and the detection (0.009 mol L(-1)) and the quantitation (0.03 cool L(-1)) limits are quite adequate for pharmaceutical analysis.

引用

页码：121 / 124

页数：4

共 35 条

[1] Quantitative Spot-Test Analysis of Metformin in Pharmaceutical Preparations Using Ultraviolet-Visible Diffuse Reflectance Spectroscopy
Matthieu Tubino
Luís Francisco Bianchessi
Marta M. D. C. Vila
Analytical Sciences, 2010, 26 : 121 - 124
[2] Direct analysis of total tannins encapsulated in silica matrices by ultraviolet-visible diffuse reflectance spectroscopy
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[3] Quantitative reflectance spot test for the determination of acetylsalicylic acid in pharmaceutical preparations
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[4] Improved design of a commercial, diffuse reflectance reactor for in-situ, ultraviolet-visible spectroscopy studies
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[5] Qualitative and simultaneous quantitative analysis of cimetidine polymorphs by ultraviolet-visible and shortwave near-infrared diffuse reflectance spectroscopy and multivariate calibration models
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[9] Rapid quantification of adulterated Panax notoginseng powder by ultraviolet-visible diffuse reflectance spectroscopy combined with chemometrics
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CHINESE JOURNAL OF ANALYTICAL CHEMISTRY, 2022, 50 (03)
[10] Determination of methyldopa in pharmaceutical formulations by combined spot test-diffuse reflectance spectroscopy
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