Polymeric Nanoparticle-Mediated Gene Delivery for Lung Cancer Treatment

被引:58
作者
Amreddy, Narsireddy [1 ,3 ]
Babu, Anish [1 ,3 ]
Muralidharan, Ranganayaki [1 ,3 ]
Munshi, Anupama [2 ,3 ]
Ramesh, Rajagopal [1 ,3 ,4 ]
机构
[1] Univ Oklahoma, Hlth Sci Ctr, Stanton L Young Biomed Res Ctr, Dept Pathol, Suite 1403,975 NE,10th St, Oklahoma City, OK 73104 USA
[2] Univ Oklahoma, Hlth Sci Ctr, Dept Radiat Oncol, Oklahoma City, OK USA
[3] Univ Oklahoma, Hlth Sci Ctr, Stephenson Canc Ctr, Oklahoma City, OK 73104 USA
[4] Univ Oklahoma, Hlth Sci Ctr, Grad Program Biomed Sci, Oklahoma City, OK 73104 USA
基金
美国国家卫生研究院;
关键词
Lung cancer; Gene therapy; Polymer nanoparticles; Receptors; Targeted delivery; FOLATE RECEPTOR-ALPHA; TARGETED CHITOSAN NANOPARTICLES; ENHANCED ANTITUMOR EFFICACY; SIRNA DELIVERY; TRANSFERRIN RECEPTOR; PLGA NANOPARTICLES; IN-VITRO; CO-DELIVERY; BIOMEDICAL APPLICATIONS; MOLECULAR-MECHANISMS;
D O I
10.1007/s41061-017-0128-5
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
In recent years, researchers have focused on targeted gene therapy for lung cancer, using nanoparticle carriers to overcome the limitations of conventional treatment methods. The main goal of targeted gene therapy is to develop more efficient therapeutic strategies by improving the bioavailability, stability, and target specificity of gene therapeutics and to reduce off-target effects. Polymer-based nanoparticles, an alternative to lipid and inorganic nanoparticles, efficiently carry nucleic acid therapeutics and are stable in vivo. Receptor-targeted delivery is a promising approach that can limit non-specific gene delivery and can be achieved by modifying the polymer nanoparticle surface with specific receptor ligands or antibodies. This review highlights the recent developments in gene delivery using synthetic and natural polymer-based nucleic acid carriers for lung cancer treatment. Various nanoparticle systems based on polymers and polymer combinations are discussed. Further, examples of targeting ligands or moieties used in targeted, polymer-based gene delivery to lung cancer are reviewed.
引用
收藏
页数:23
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