Novel boronic acid derivatives of bis(indolyl) methane as anti-MRSA agents

被引：30

作者：

Mandal, Santi M. ^{[1
]}

Pegu, Rupa ^{[2
]}

Porto, William F. ^{[3
]}

Franco, Octavio L. ^{[4
]}

Pratihar, Sanjay ^{[2
]}

机构：

[1] Indian Inst Technol Kharagpur, Cent Res Facil, Kharagpur 721302, W Bengal, India

[2] Tezpur Univ, Dept Chem Sci, Napaam 784028, Assam, India

[3] Univ Catolica Brasilia, Ctr Anal Prote & Bioquim, Programa Posgrad Ciencias Genom & Biotecnol, Brasilia, DF, Brazil

[4] Univ Catolica Dom Bosco, Posgrad Biotecnol, Inova Biotech 4S, Campo Grande, MS, Brazil

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2017年 / 27卷 / 10期

关键词：

Bis(indolyl) methane; MRSA; New generation antibiotics; Bacterial cell wall; Leucyl-tRNA synthetase;

D O I：

10.1016/j.bmcl.2017.03.070

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Towards the search for a new generation of antibiotics to control methicillin-resistant Staphylococcus aureus (MRSA), the design and synthesis of various bis indolyl methane (BIM) derivatives based on their different electron donor and acceptor properties of the substituents have been made, in which boronic acid derivatives of BIM are found to be active against MRSA. The observed evidence with the lead compound reveals their strong anti-MRSA activity, which paves the way of design and further development of a new generation antibiotics. (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：2135 / 2138

页数：4

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