Neonatal ventral hippocampal lesions disrupt set-shifting ability in adult rats

被引：28

作者：

Brady, Anne Marie ^{[1
]}

机构：

[1] St Marys Coll Maryland, Dept Psychol, St Marys City, MD 20686 USA

来源：

BEHAVIOURAL BRAIN RESEARCH | 2009年 / 205卷 / 01期

关键词：

Schizophrenia; Hippocampus; Set-shifting; Prefrontal cortex; Neonatal ventral hippocampal lesion model; Behavioral flexibility; MEDIAL PREFRONTAL CORTEX; DEVELOPMENTAL ANIMAL-MODEL; FRONTAL-LOBE DAMAGE; NUCLEUS-ACCUMBENS; BEHAVIORAL FLEXIBILITY; CHRONIC-SCHIZOPHRENIA; RECEPTOR BLOCKADE; CORTICAL-NEURONS; INACTIVATION; DEFICITS;

D O I：

10.1016/j.bbr.2009.07.025

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Set-shifting in a T-maze task was assessed in rats with a neonatal ventral hippocampal lesion (NVHL), a proposed animal model of schizophrenia. NVHL animals tested as adults were impaired in shifting to a new rule; an increase in perseverative errors suggested that this impairment stemmed from an inability to suppress the previously learned strategy. The NVHL animals' performance is reminiscent of humans with preftontal damage and patients with schizophrenia. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：294 / 298

页数：5

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