Association of HLA-B*1502 allele and carbamazepine-induced Stevens-Johnson syndrome among Indians

被引：228

作者：

Mehta, Timir Y. ^{[1
]}

Prajapati, Laxman M. ^{[2
]}

Mittal, Bharti ^{[3
]}

Joshi, Chaitanya G. ^{[4
]}

Sheth, Jayesh J. ^{[5
]}

Patel, Dinesh B. ^{[6
]}

Dave, Dinkar M. ^{[1
]}

Goyal, Ramesh K. ^{[7
]}

机构：

[1] Dr Rasiklal Shah Sarvajanik Hosp, Modasa 383315, Gujarat, India

[2] Shri BM Shah Coll Pharmaceut Educ & Res, Modasa 383315, India

[3] Krishna Inst Med Sci, Dept Mol Biol, Hyderabad 500003, Andhra Pradesh, India

[4] Anand Agr Univ, Dept Anim Biotechnol, Anand 388001, Gujarat, India

[5] Inst Human Genet, Ahmadabad 380015, Gujarat, India

[6] Deep Hosp, Modasa 383315, India

[7] LM Coll Pharm, Dept Pharmacol, Ahmadabad 380009, Gujarat, India

来源：

INDIAN JOURNAL OF DERMATOLOGY VENEREOLOGY & LEPROLOGY | 2009年 / 75卷 / 06期

关键词：

Carbamazepine; HLA-B*1502; Hindu; Indian; Stevens-Johnson syndrome; HLA-B; CUTANEOUS REACTIONS; POPULATION; CW; FREQUENCIES;

D O I：

10.4103/0378-6323.57718

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Background: Stevens-Johnson Syndrome (SJS) and toxic epidermal necrolysis are severe cutaneous reactions caused by certain drugs, including antiepileptic carbamazepine. A strong association has been reported between human leucocyte antigen (HLA)-B*1502 and carbamazepine-induced SJS in Han Chinese patients. European studies suggested that HLA-B*1502 is not a universal marker but is ethnicity-specific for Asians. Aim: To study the association between HLA-B*1502 and carbamazepine-induced SJS in Indian patients. Methods: Eight individuals who fulfilled the diagnostic criteria of SJS induced by carbamazepine were identified and HLA-B molecular typing was performed. HLA-B genotyping was carried out by polymerase chain reaction using sequence-specific primers. Results: Out of eight patients studied for genotype, six patients were found to have the HLA-B*1502 allele. Conclusion: This study suggests an association between HLA-B*1502 and carbamazepine-induced SJS in Indian patients.

引用

页码：579 / 582

页数：4

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