One-Step Fabrication of a Microfluidic Device with an Integrated Membrane and Embedded Reagents by Multimaterial 3D Printing

被引:103
|
作者
Li, Feng [1 ,2 ,3 ,4 ]
Smejkal, Petr [1 ]
Macdonald, Niall P. [1 ,4 ]
Guijt, Rosanne M. [2 ,3 ,4 ]
Breadmore, Michael C. [1 ,4 ]
机构
[1] Univ Tasmania, Sch Chem, Australian Ctr Res Separat Sci, Private Bag 75, Hobart, Tas 7001, Australia
[2] Univ Tasmania, Sch Med, Private Bag 26, Hobart, Tas 7001, Australia
[3] Univ Tasmania, Australian Ctr Res Separat Sci, Private Bag 26, Hobart, Tas 7001, Australia
[4] Univ Tasmania, Sch Chem, ARC Ctr Excellence Electromat Sci ACES, Private Bag 75, Hobart, Tas 7001, Australia
基金
澳大利亚研究理事会;
关键词
REACTIONWARE; NITRATE; CHIP;
D O I
10.1021/acs.analchem.7b00409
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
One of the largest impediments in the development of microfluidic-based smart sensing systems is the manufacturability of integrated, complex devices. Here we propose multimaterial 3D printing for the fabrication of such devices in a single step. A microfluidic device containing an integrated porous membrane and embedded liquid reagents was made by 3D printing and applied for the analysis of nitrate in soil. The manufacture of the integrated, sealed device was realized as a single print within 30 min. The body of the device was printed in transparent acrylonitrile butadiene styrene (ABS) and contained a 400 mu m wide structure printed from a commercially available composite filament. The composite filament can be turned into a porous material through dissolution of a water-soluble material. Liquid reagents were integrated by briefly pausing the printing before resuming for sealing the device. The devices were evaluated by the determination of nitrate in a soil slurry containing zinc particles for the reduction of nitrate to nitrite using the Griess reagent. Using a consumer digital camera, the linear range of the detector response ranged from 0 to 60 ppm, covering the normal range of nitrate in soil. To ensure that the sealing of the reagent chamber is maintained, aqueous reagents should be avoided. When using the nonaqueous reagent, the multimaterial device containing the Griess reagent could be stored for over 4 days but increased the detection range to 100500 ppm. Multimaterial 3D printing is a potentially new approach for the manufacture of microfluidic devices with multiple integrated functional components.
引用
收藏
页码:4701 / 4707
页数:7
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